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Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy

Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer worldwide and the second most frequent cause of cancer death. The aim of this study is to identify the association between the expression of long non-coding RNA (lncRNA) MIR22HG and the clinical and tumor characteristics of...

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Autores principales: Dong, Yuan, Yan, Weiwei, Zhang, Shi-Long, Zhang, Mu-Zi-He, Zhou, Yan-Ping, Ling, Hai-Hui, Ning, Meng, Zhao, Yanling, Huang, Ang, Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768384/
https://www.ncbi.nlm.nih.gov/pubmed/29371967
http://dx.doi.org/10.18632/oncotarget.23110
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author Dong, Yuan
Yan, Weiwei
Zhang, Shi-Long
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Ling, Hai-Hui
Ning, Meng
Zhao, Yanling
Huang, Ang
Zhang, Ping
author_facet Dong, Yuan
Yan, Weiwei
Zhang, Shi-Long
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Ling, Hai-Hui
Ning, Meng
Zhao, Yanling
Huang, Ang
Zhang, Ping
author_sort Dong, Yuan
collection PubMed
description Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer worldwide and the second most frequent cause of cancer death. The aim of this study is to identify the association between the expression of long non-coding RNA (lncRNA) MIR22HG and the clinical and tumor characteristics of patients with HCC, and to explore the prognostic significance of lncRNA MIR22HG on patients with HCC. We retrospectively reviewed 127 patients with HCC(42 female, 85 male) who were managed in our hospital between May 1(st) 2010 and June 30(th) 2016. The expressions of lncRNA MIR22HG were detected by real-time PCR. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models. For the entire cohort of 127 patients, the normalized real-time PCR showed that the expression of lncRNA MIR22HG was lower in HCC tissues compared with corresponding nontumorous tissues. MTT assay showed that si-MIR22HG remarkably inhibited the proliferation tumor cells in three HCC cell lines including SMMC-7721, Huh-7 and Hep3B. Moreover, under-expression of MIR22HG was closely related to tumor encapsulation, microvascular invasion (MVI), and TNM stage. Cox proportional hazards analysis demonstrated that lncRNA MIR22HG under-expression was an independent risk factor associated with the prognosis of patients with HCC. In conclusion, we found that lncRNA MIR22HG expressed significantly lower in HCC tissues compared with non-tumorous tissues. Under-expression of lncRNAMIR22HG was an independent risk factor associated with the prognosis of patients with HCC.
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spelling pubmed-57683842018-01-25 Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy Dong, Yuan Yan, Weiwei Zhang, Shi-Long Zhang, Mu-Zi-He Zhou, Yan-Ping Ling, Hai-Hui Ning, Meng Zhao, Yanling Huang, Ang Zhang, Ping Oncotarget Research Paper Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer worldwide and the second most frequent cause of cancer death. The aim of this study is to identify the association between the expression of long non-coding RNA (lncRNA) MIR22HG and the clinical and tumor characteristics of patients with HCC, and to explore the prognostic significance of lncRNA MIR22HG on patients with HCC. We retrospectively reviewed 127 patients with HCC(42 female, 85 male) who were managed in our hospital between May 1(st) 2010 and June 30(th) 2016. The expressions of lncRNA MIR22HG were detected by real-time PCR. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models. For the entire cohort of 127 patients, the normalized real-time PCR showed that the expression of lncRNA MIR22HG was lower in HCC tissues compared with corresponding nontumorous tissues. MTT assay showed that si-MIR22HG remarkably inhibited the proliferation tumor cells in three HCC cell lines including SMMC-7721, Huh-7 and Hep3B. Moreover, under-expression of MIR22HG was closely related to tumor encapsulation, microvascular invasion (MVI), and TNM stage. Cox proportional hazards analysis demonstrated that lncRNA MIR22HG under-expression was an independent risk factor associated with the prognosis of patients with HCC. In conclusion, we found that lncRNA MIR22HG expressed significantly lower in HCC tissues compared with non-tumorous tissues. Under-expression of lncRNAMIR22HG was an independent risk factor associated with the prognosis of patients with HCC. Impact Journals LLC 2017-12-11 /pmc/articles/PMC5768384/ /pubmed/29371967 http://dx.doi.org/10.18632/oncotarget.23110 Text en Copyright: © 2017 Dong et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Dong, Yuan
Yan, Weiwei
Zhang, Shi-Long
Zhang, Mu-Zi-He
Zhou, Yan-Ping
Ling, Hai-Hui
Ning, Meng
Zhao, Yanling
Huang, Ang
Zhang, Ping
Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title_full Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title_fullStr Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title_full_unstemmed Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title_short Prognostic values of long non-coding RNA MIR22HG for patients with hepatocellular carcinoma after hepatectomy
title_sort prognostic values of long non-coding rna mir22hg for patients with hepatocellular carcinoma after hepatectomy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768384/
https://www.ncbi.nlm.nih.gov/pubmed/29371967
http://dx.doi.org/10.18632/oncotarget.23110
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