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Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells

The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In...

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Detalles Bibliográficos
Autores principales: Agrawal, Siddarth, Wozniak, Marta, Luc, Mateusz, Walaszek, Kinga, Pielka, Ewa, Szeja, Wieslaw, Pastuch-Gawolek, Gabriela, Gamian, Andrzej, Ziolkowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768394/
https://www.ncbi.nlm.nih.gov/pubmed/29371977
http://dx.doi.org/10.18632/oncotarget.23170
Descripción
Sumario:The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. Linking glucose and anticancer agent presents an approach that exploits the Warburg effect. Targeting dysfunctional glycometabolism and increased glucose absorption is emerging as a promising anticancer strategy.