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Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells
The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768394/ https://www.ncbi.nlm.nih.gov/pubmed/29371977 http://dx.doi.org/10.18632/oncotarget.23170 |
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author | Agrawal, Siddarth Wozniak, Marta Luc, Mateusz Walaszek, Kinga Pielka, Ewa Szeja, Wieslaw Pastuch-Gawolek, Gabriela Gamian, Andrzej Ziolkowski, Piotr |
author_facet | Agrawal, Siddarth Wozniak, Marta Luc, Mateusz Walaszek, Kinga Pielka, Ewa Szeja, Wieslaw Pastuch-Gawolek, Gabriela Gamian, Andrzej Ziolkowski, Piotr |
author_sort | Agrawal, Siddarth |
collection | PubMed |
description | The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. Linking glucose and anticancer agent presents an approach that exploits the Warburg effect. Targeting dysfunctional glycometabolism and increased glucose absorption is emerging as a promising anticancer strategy. |
format | Online Article Text |
id | pubmed-5768394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57683942018-01-25 Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells Agrawal, Siddarth Wozniak, Marta Luc, Mateusz Walaszek, Kinga Pielka, Ewa Szeja, Wieslaw Pastuch-Gawolek, Gabriela Gamian, Andrzej Ziolkowski, Piotr Oncotarget Research Paper The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. Linking glucose and anticancer agent presents an approach that exploits the Warburg effect. Targeting dysfunctional glycometabolism and increased glucose absorption is emerging as a promising anticancer strategy. Impact Journals LLC 2017-12-11 /pmc/articles/PMC5768394/ /pubmed/29371977 http://dx.doi.org/10.18632/oncotarget.23170 Text en Copyright: © 2017 Agrawal et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Agrawal, Siddarth Wozniak, Marta Luc, Mateusz Walaszek, Kinga Pielka, Ewa Szeja, Wieslaw Pastuch-Gawolek, Gabriela Gamian, Andrzej Ziolkowski, Piotr Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title_full | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title_fullStr | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title_full_unstemmed | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title_short | Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
title_sort | insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768394/ https://www.ncbi.nlm.nih.gov/pubmed/29371977 http://dx.doi.org/10.18632/oncotarget.23170 |
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