Cargando…

ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor

Gastrointestinal stromal tumor (GIST) is the most common sarcoma, often resulting from a KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutation. The lineage transcription factor ETV1 is expressed similarly in GISTs regardless of malignant potential. Although the related transcription...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Shan, Seifert, Adrian M., Zhang, Jennifer Q., Kim, Teresa S., Bowler, Timothy G., Cavnar, Michael J., Medina, Benjamin D., Vitiello, Gerardo A., Rossi, Ferdinand, Loo, Jennifer K., Param, Nesteene J., DeMatteo, Ronald P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768396/ https://www.ncbi.nlm.nih.gov/pubmed/29371979 http://dx.doi.org/10.18632/oncotarget.23173

Ejemplares similares

The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor
por: Zhang, Jennifer Q., et al.
Publicado: (2020)

Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity
por: Medina, Benjamin D., et al.
Publicado: (2019)

Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages
por: Cavnar, Michael J, et al.
Publicado: (2014)

Imatinib potentiates anti-tumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
por: Balachandran, Vinod P., et al.
Publicado: (2011)

Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors
por: Sakamaki, Keiichi, et al.
Publicado: (2020)

Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
por: Mesquita, Diana, et al.
Publicado: (2015)

ADRB2 Regulates the Proliferation and Metastasis of Gastrointestinal Stromal Tumor Cells by Enhancing the ETV1-c-KIT Signaling
por: Chen, Sijun, et al.
Publicado: (2023)

Low-Grade Ovarian Stromal Tumors with Genetic Alterations of the Wnt/β-Catenin Pathway That Is Crucial in Ovarian Follicle Development and Regulation
por: Zhang, Gloria, et al.
Publicado: (2022)

Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas
por: Zhou, Yiqiang, et al.
Publicado: (2019)

Gene Expression Network Analysis of ETV1 Reveals KCTD10 as a Novel Prognostic Biomarker in Gastrointestinal Stromal Tumor
por: Kubota, Daisuke, et al.
Publicado: (2013)

Are liver nested stromal epithelial tumors always low aggressive?
por: Meletani, Tania, et al.
Publicado: (2017)

WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway
por: Yang, Dongmei, et al.
Publicado: (2020)

The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma
por: Wang, Kaiting, et al.
Publicado: (2022)

ETV1 inhibition depressed M2 polarization of tumor-associated macrophage and cell process in gastrointestinal stromal tumor via down-regulating PDE3A
por: Guo, Xueyan, et al.
Publicado: (2023)

Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers
por: De, Pradip, et al.
Publicado: (2016)

Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants
por: O'Brien, Katie M., et al.
Publicado: (2013)

An Aggressively Enlarging Benign Mixed Epithelial Stromal Tumor (MEST) of the Kidney
por: Janes, W. C. Ian, et al.
Publicado: (2022)

Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells
por: Peng, Xinrong, et al.
Publicado: (2012)

WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
por: Li, Xin, et al.
Publicado: (2019)

Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors In Vitro: Antitumoral Effects
por: Jin, Xi-Feng, et al.
Publicado: (2020)

Establishment of a transgenic mouse to model ETV7 expressing human tumors
por: Numata, Masashi, et al.
Publicado: (2018)

Stromally Expressed β-Catenin Modulates Wnt9b Signaling in the Ureteric Epithelium
por: Boivin, Felix J., et al.
Publicado: (2015)

Gastrointestinal stromal tumor of unusual phenotype after imatinib treatment: A case report and diagnostic utility of ETV1 mRNA in situ hybridization
por: Jung, Minsun, et al.
Publicado: (2017)

MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer
por: Doha, Zinab O., et al.
Publicado: (2023)

Activation of the Canonical Wnt/β-Catenin Pathway in ATF3-Induced Mammary Tumors
por: Yan, Leqin, et al.
Publicado: (2011)

Wnt/β-Catenin activation promotes prostate tumor progression in a mouse model
por: Yu, Xiuping, et al.
Publicado: (2010)

DACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway
por: Wang, Jing, et al.
Publicado: (2018)

PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer
por: Xia, Boning, et al.
Publicado: (2020)

Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5
por: Currie, Simon L., et al.
Publicado: (2017)

MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer
por: Li, Tingting, et al.
Publicado: (2016)

CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway
por: Li, Xiaofen, et al.
Publicado: (2017)

SH3BP2 Silencing Increases miRNAs Targeting ETV1 and Microphthalmia-Associated Transcription Factor, Decreasing the Proliferation of Gastrointestinal Stromal Tumors
por: Proaño-Pérez, Elizabeth, et al.
Publicado: (2022)

Elevated ETV6 Expression in Glioma Promotes an Aggressive In Vitro Phenotype Associated with Shorter Patient Survival
por: Xiong, Zhang, et al.
Publicado: (2022)

γ-Catenin Overexpression in AML Patients May Promote Tumor Cell Survival via Activation of the Wnt/β-Catenin Axis
por: Qian, Jiejin, et al.
Publicado: (2020)

Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations
por: O’Brien, Katie M, et al.
Publicado: (2013)

Identifying the stromal cell type that contributes to tumor aggressiveness associated with carbonic anhydrase IX
por: Bose, Pinaki, et al.
Publicado: (2013)

Extremely Aggressive Mesenteric Extragastrointestinal Stromal Tumor: A Case Report and Literature Review
por: Abidoye, Oluseyi, et al.
Publicado: (2022)

Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer
por: Chen, Jiayu, et al.
Publicado: (2020)

Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer
por: Morrow, K. Adam, et al.
Publicado: (2016)

Immunoexpression of Wnt/β-catenin signaling pathway proteins in ameloblastoma and calcifying cystic odontogenic tumor
por: Dutra, Sabrina-Nogueira, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hsdcbu9h54ucujnqb9trib1aet