Cargando…
Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer
BACKGROUND/AIMS: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status. METHOD...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768530/ https://www.ncbi.nlm.nih.gov/pubmed/27093978 http://dx.doi.org/10.3904/kjim.2015.158 |
_version_ | 1783292718733066240 |
---|---|
author | Baek, Min Young Ahn, Hee Kyung Park, Kyu Ree Park, Hwa-Sun Kang, Shin Myung Park, Inkeun Kim, Young Saing Hong, Junshik Sym, Sun Jin Park, Jinny Lee, Jae Hoon Shin, Dong Bok Cho, Eun Kyung |
author_facet | Baek, Min Young Ahn, Hee Kyung Park, Kyu Ree Park, Hwa-Sun Kang, Shin Myung Park, Inkeun Kim, Young Saing Hong, Junshik Sym, Sun Jin Park, Jinny Lee, Jae Hoon Shin, Dong Bok Cho, Eun Kyung |
author_sort | Baek, Min Young |
collection | PubMed |
description | BACKGROUND/AIMS: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status. METHODS: We retrospectively investigated the medical records of 259 patients diagnosed with advanced NSCLC from January 2010 to August 2013, who were tested for EGFR mutations. The time from the diagnosis of advanced NSCLC to the development of BM and the overall median survival after BM development (BM-OS) were evaluated and compared by EGFR mutational status. RESULTS: Sixty-seven patients (25.9%) developed BM. Synchronous BM occurred more often in patients with EGFR mutation type (MT) (n = 20, 27.4%) compared with EGFR wild type (WT) (n = 27, 14.5%, p < 0.009). The median BM-OS was significantly longer in patients with EGFR MT than in those with EGFR WT (25.7 months vs. 3.8 months, p < 0.001), and a similar trend was noticed for patients with synchronous BM (25.7 months for EGFR MT vs. 6.8 months for EGFR WT, p < 0.001). However, in patients with metachronous BM development, the difference in BM-OS between patients with EGFR MT (14.6 months) and EGFR WT (2.5 months) did not reach statistical significance (p = 0.230). CONCLUSIONS: Synchronous BM was more common in NSCLC patients with EGFR MT than in those with EGFR WT. However, EGFR mutations were associated with significantly longer median BM-OS, especially when the brain was the first metastatic site. |
format | Online Article Text |
id | pubmed-5768530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-57685302018-01-19 Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer Baek, Min Young Ahn, Hee Kyung Park, Kyu Ree Park, Hwa-Sun Kang, Shin Myung Park, Inkeun Kim, Young Saing Hong, Junshik Sym, Sun Jin Park, Jinny Lee, Jae Hoon Shin, Dong Bok Cho, Eun Kyung Korean J Intern Med Original Article BACKGROUND/AIMS: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status. METHODS: We retrospectively investigated the medical records of 259 patients diagnosed with advanced NSCLC from January 2010 to August 2013, who were tested for EGFR mutations. The time from the diagnosis of advanced NSCLC to the development of BM and the overall median survival after BM development (BM-OS) were evaluated and compared by EGFR mutational status. RESULTS: Sixty-seven patients (25.9%) developed BM. Synchronous BM occurred more often in patients with EGFR mutation type (MT) (n = 20, 27.4%) compared with EGFR wild type (WT) (n = 27, 14.5%, p < 0.009). The median BM-OS was significantly longer in patients with EGFR MT than in those with EGFR WT (25.7 months vs. 3.8 months, p < 0.001), and a similar trend was noticed for patients with synchronous BM (25.7 months for EGFR MT vs. 6.8 months for EGFR WT, p < 0.001). However, in patients with metachronous BM development, the difference in BM-OS between patients with EGFR MT (14.6 months) and EGFR WT (2.5 months) did not reach statistical significance (p = 0.230). CONCLUSIONS: Synchronous BM was more common in NSCLC patients with EGFR MT than in those with EGFR WT. However, EGFR mutations were associated with significantly longer median BM-OS, especially when the brain was the first metastatic site. The Korean Association of Internal Medicine 2018-01 2016-04-20 /pmc/articles/PMC5768530/ /pubmed/27093978 http://dx.doi.org/10.3904/kjim.2015.158 Text en Copyright © 2018 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Baek, Min Young Ahn, Hee Kyung Park, Kyu Ree Park, Hwa-Sun Kang, Shin Myung Park, Inkeun Kim, Young Saing Hong, Junshik Sym, Sun Jin Park, Jinny Lee, Jae Hoon Shin, Dong Bok Cho, Eun Kyung Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title | Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title_full | Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title_fullStr | Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title_full_unstemmed | Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title_short | Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
title_sort | epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768530/ https://www.ncbi.nlm.nih.gov/pubmed/27093978 http://dx.doi.org/10.3904/kjim.2015.158 |
work_keys_str_mv | AT baekminyoung epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT ahnheekyung epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT parkkyuree epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT parkhwasun epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT kangshinmyung epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT parkinkeun epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT kimyoungsaing epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT hongjunshik epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT symsunjin epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT parkjinny epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT leejaehoon epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT shindongbok epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer AT choeunkyung epidermalgrowthfactorreceptormutationandpatternofbrainmetastasisinpatientswithnonsmallcelllungcancer |