Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus

BACKGROUND: Calcitonin gene-related peptide (CGRP) plays a major role in the pathogenesis of migraine and other primary headaches. Spinal trigeminal neurons integrate nociceptive afferent input from trigeminal tissues including intracranial afferents, and their activity is thought to reflect facial...

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Detalles Bibliográficos
Autores principales: Fischer, Michael J. M., Schmidt, Jakob, Koulchitsky, Stanislav, Klussmann, Sven, Vater, Axel, Messlinger, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768576/
https://www.ncbi.nlm.nih.gov/pubmed/29335794
http://dx.doi.org/10.1186/s10194-018-0832-8

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