A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neu...

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Detalles Bibliográficos
Autores principales: Kankowski, Svenja, Förstera, Benjamin, Winkelmann, Aline, Knauff, Pina, Wanker, Erich E., You, Xintian A., Semtner, Marcus, Hetsch, Florian, Meier, Jochen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768626/
https://www.ncbi.nlm.nih.gov/pubmed/29375302
http://dx.doi.org/10.3389/fnmol.2017.00439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768626/
https://www.ncbi.nlm.nih.gov/pubmed/29375302
http://dx.doi.org/10.3389/fnmol.2017.00439

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