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Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives

Spinal cord injury (SCI), resulting in para- and tetraplegia caused by the partial or complete disruption of descending motor and ascending sensory neurons, represents a complex neurological condition that remains incurable. Following SCI, numerous obstacles comprising of the loss of neural tissue (...

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Autores principales: Liu, Shengwen, Schackel, Thomas, Weidner, Norbert, Puttagunta, Radhika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768640/
https://www.ncbi.nlm.nih.gov/pubmed/29375316
http://dx.doi.org/10.3389/fncel.2017.00430
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author Liu, Shengwen
Schackel, Thomas
Weidner, Norbert
Puttagunta, Radhika
author_facet Liu, Shengwen
Schackel, Thomas
Weidner, Norbert
Puttagunta, Radhika
author_sort Liu, Shengwen
collection PubMed
description Spinal cord injury (SCI), resulting in para- and tetraplegia caused by the partial or complete disruption of descending motor and ascending sensory neurons, represents a complex neurological condition that remains incurable. Following SCI, numerous obstacles comprising of the loss of neural tissue (neurons, astrocytes, and oligodendrocytes), formation of a cavity, inflammation, loss of neuronal circuitry and function must be overcome. Given the multifaceted primary and secondary injury events that occur with SCI treatment options are likely to require combinatorial therapies. While several methods have been explored, only the intersection of two, cell transplantation and biomaterial implantation, will be addressed in detail here. Owing to the constant advance of cell culture technologies, cell-based transplantation has come to the forefront of SCI treatment in order to replace/protect damaged tissue and provide physical as well as trophic support for axonal regrowth. Biomaterial scaffolds provide cells with a protected environment from the surrounding lesion, in addition to bridging extensive damage and providing physical and directional support for axonal regrowth. Moreover, in this combinatorial approach cell transplantation improves scaffold integration and therefore regenerative growth potential. Here, we review the advances in combinatorial therapies of Schwann cells (SCs), astrocytes, olfactory ensheathing cells (OECs), mesenchymal stem cells, as well as neural stem and progenitor cells (NSPCs) with various biomaterial scaffolds.
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spelling pubmed-57686402018-01-26 Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives Liu, Shengwen Schackel, Thomas Weidner, Norbert Puttagunta, Radhika Front Cell Neurosci Neuroscience Spinal cord injury (SCI), resulting in para- and tetraplegia caused by the partial or complete disruption of descending motor and ascending sensory neurons, represents a complex neurological condition that remains incurable. Following SCI, numerous obstacles comprising of the loss of neural tissue (neurons, astrocytes, and oligodendrocytes), formation of a cavity, inflammation, loss of neuronal circuitry and function must be overcome. Given the multifaceted primary and secondary injury events that occur with SCI treatment options are likely to require combinatorial therapies. While several methods have been explored, only the intersection of two, cell transplantation and biomaterial implantation, will be addressed in detail here. Owing to the constant advance of cell culture technologies, cell-based transplantation has come to the forefront of SCI treatment in order to replace/protect damaged tissue and provide physical as well as trophic support for axonal regrowth. Biomaterial scaffolds provide cells with a protected environment from the surrounding lesion, in addition to bridging extensive damage and providing physical and directional support for axonal regrowth. Moreover, in this combinatorial approach cell transplantation improves scaffold integration and therefore regenerative growth potential. Here, we review the advances in combinatorial therapies of Schwann cells (SCs), astrocytes, olfactory ensheathing cells (OECs), mesenchymal stem cells, as well as neural stem and progenitor cells (NSPCs) with various biomaterial scaffolds. Frontiers Media S.A. 2018-01-11 /pmc/articles/PMC5768640/ /pubmed/29375316 http://dx.doi.org/10.3389/fncel.2017.00430 Text en Copyright © 2018 Liu, Schackel, Weidner and Puttagunta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Shengwen
Schackel, Thomas
Weidner, Norbert
Puttagunta, Radhika
Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title_full Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title_fullStr Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title_full_unstemmed Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title_short Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
title_sort biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768640/
https://www.ncbi.nlm.nih.gov/pubmed/29375316
http://dx.doi.org/10.3389/fncel.2017.00430
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