Cargando…
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma
In fibrolamellar hepatocellular carcinoma a single genetic deletion results in the fusion of the first exon of the heat shock protein 40, DNAJB1, which encodes the J domain, with exons 2–10 of the catalytic subunit of protein kinase A, PRKACA. This produces an enzymatically active chimeric protein J...
Autores principales: | Tomasini, Michael D., Wang, Yingjie, Karamafrooz, Adak, Li, Geoffrey, Beuming, Thijs, Gao, Jiali, Taylor, Susan S., Veglia, Gianluigi, Simon, Sanford M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768683/ https://www.ncbi.nlm.nih.gov/pubmed/29335433 http://dx.doi.org/10.1038/s41598-017-18956-w |
Ejemplares similares
-
Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA
por: Neumayer, Christoph, et al.
Publicado: (2023) -
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma
por: Vyas, Monika, et al.
Publicado: (2019) -
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
por: Bauer, Jens, et al.
Publicado: (2022) -
DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling
por: Kim, Stephanie S., et al.
Publicado: (2022) -
Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity
por: Walker, Caitlin, et al.
Publicado: (2019)