Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains. Here we perform a...

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Detalles Bibliográficos
Autores principales: Zhang, Shengzhe, Zhang, Meiying, Jing, Ying, Yin, Xia, Ma, Pengfei, Zhang, Zhenfeng, Wang, Xiaojie, Di, Wen, Zhuang, Guanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768685/
https://www.ncbi.nlm.nih.gov/pubmed/29335437
http://dx.doi.org/10.1038/s41467-017-02693-9

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