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The high concentration of progesterone is harmful for endometrial receptivity and decidualization
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the pos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768702/ https://www.ncbi.nlm.nih.gov/pubmed/29335465 http://dx.doi.org/10.1038/s41598-017-18643-w |
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author | Liang, Yu-Xiang Liu, Li Jin, Zhi-Yong Liang, Xiao-Huan Fu, Yong-Sheng Gu, Xiao-Wei Yang, Zeng-Ming |
author_facet | Liang, Yu-Xiang Liu, Li Jin, Zhi-Yong Liang, Xiao-Huan Fu, Yong-Sheng Gu, Xiao-Wei Yang, Zeng-Ming |
author_sort | Liang, Yu-Xiang |
collection | PubMed |
description | Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization. Our data indicate that excess progesterone is not only harmful for mouse implantation, but also impairs mouse decidualization. In excess progesterone-treated mice, the impaired LIF/STAT3 pathway and dysregulated endoplasmic reticulum stress may lead to the inhibition of embryo implantation and decidualization. It is possible that the decrease in birth weight of excess progesterone-treated mice is due to a compromised embryo implantation and decidualization. Furthermore, excess progesterone compromises in vitro decidualization of human endometrial stromal cells. |
format | Online Article Text |
id | pubmed-5768702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57687022018-01-25 The high concentration of progesterone is harmful for endometrial receptivity and decidualization Liang, Yu-Xiang Liu, Li Jin, Zhi-Yong Liang, Xiao-Huan Fu, Yong-Sheng Gu, Xiao-Wei Yang, Zeng-Ming Sci Rep Article Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization. Our data indicate that excess progesterone is not only harmful for mouse implantation, but also impairs mouse decidualization. In excess progesterone-treated mice, the impaired LIF/STAT3 pathway and dysregulated endoplasmic reticulum stress may lead to the inhibition of embryo implantation and decidualization. It is possible that the decrease in birth weight of excess progesterone-treated mice is due to a compromised embryo implantation and decidualization. Furthermore, excess progesterone compromises in vitro decidualization of human endometrial stromal cells. Nature Publishing Group UK 2018-01-15 /pmc/articles/PMC5768702/ /pubmed/29335465 http://dx.doi.org/10.1038/s41598-017-18643-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Liang, Yu-Xiang Liu, Li Jin, Zhi-Yong Liang, Xiao-Huan Fu, Yong-Sheng Gu, Xiao-Wei Yang, Zeng-Ming The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title | The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title_full | The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title_fullStr | The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title_full_unstemmed | The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title_short | The high concentration of progesterone is harmful for endometrial receptivity and decidualization |
title_sort | high concentration of progesterone is harmful for endometrial receptivity and decidualization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768702/ https://www.ncbi.nlm.nih.gov/pubmed/29335465 http://dx.doi.org/10.1038/s41598-017-18643-w |
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