The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding

Current therapeutic antibodies such as Trastuzumab, are typically of the blood circulatory IgG1 class (Cκ/ CHγ1). Due to the binding to Her2 also present on normal cell surfaces, side effects such as cardiac failure can sometimes be associated with such targeted therapy. Using antibody isotype swapp...

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Detalles Bibliográficos
Autores principales: Lua, Wai-Heng, Ling, Wei-Li, Yeo, Joshua Yi, Poh, Jun-Jie, Lane, David Philip, Gan, Samuel Ken-En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768722/
https://www.ncbi.nlm.nih.gov/pubmed/29335579
http://dx.doi.org/10.1038/s41598-017-18892-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768722/
https://www.ncbi.nlm.nih.gov/pubmed/29335579
http://dx.doi.org/10.1038/s41598-017-18892-9

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