Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

Neurological drugs are often associated with serious side effects, yet drug screens typically focus only on efficacy. We demonstrate a novel paradigm utilizing high-throughput in vivo electrophysiology and brain activity patterns (BAPs). A platform with high sensitivity records local field potential...

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Detalles Bibliográficos
Autores principales: Eimon, Peter M., Ghannad-Rezaie, Mostafa, De Rienzo, Gianluca, Allalou, Amin, Wu, Yuelong, Gao, Mu, Roy, Ambrish, Skolnick, Jeffrey, Yanik, Mehmet Fatih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768723/
https://www.ncbi.nlm.nih.gov/pubmed/29335539
http://dx.doi.org/10.1038/s41467-017-02404-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768723/
https://www.ncbi.nlm.nih.gov/pubmed/29335539
http://dx.doi.org/10.1038/s41467-017-02404-4

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