Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL

Published molecular profiling studies in patients with lymphoma suggested the influence of hypoxia inducible factor-1 alpha (HIF1α) targets in prognosis of DLBCL. Yet, the role of hypoxia in hematological malignancies remains unclear. We observed that activation of HIF1α resulted in global translati...

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Detalles Bibliográficos
Autores principales: Bhalla, Kavita, Jaber, Sausan, Nahid M., Nanaji, Underwood, Karen, Beheshti, Afshin, Landon, Ari, Bhandary, Binny, Bastian, Paul, Evens, Andrew M., Haley, John, Polster, Brian, Gartenhaus, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768748/
https://www.ncbi.nlm.nih.gov/pubmed/29335581
http://dx.doi.org/10.1038/s41598-018-19182-8

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