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Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor his...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768767/ https://www.ncbi.nlm.nih.gov/pubmed/29335408 http://dx.doi.org/10.1038/s41467-017-02665-z |
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author | Ju, Ji-Min Jung, Min Ho Nam, Giri Kim, Woojin Oh, Sehwa Kim, Hyun Duk Kim, Joo Young Chang, Jun Lee, Sung Hak Park, Gyeong Sin Min, Chang-Ki Lee, Dong-Sup Kim, Moon Gyo Choi, Kyungho Choi, Eun Young |
author_facet | Ju, Ji-Min Jung, Min Ho Nam, Giri Kim, Woojin Oh, Sehwa Kim, Hyun Duk Kim, Joo Young Chang, Jun Lee, Sung Hak Park, Gyeong Sin Min, Chang-Ki Lee, Dong-Sup Kim, Moon Gyo Choi, Kyungho Choi, Eun Young |
author_sort | Ju, Ji-Min |
collection | PubMed |
description | Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8(+) T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60(+) hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors. |
format | Online Article Text |
id | pubmed-5768767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57687672018-01-19 Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen Ju, Ji-Min Jung, Min Ho Nam, Giri Kim, Woojin Oh, Sehwa Kim, Hyun Duk Kim, Joo Young Chang, Jun Lee, Sung Hak Park, Gyeong Sin Min, Chang-Ki Lee, Dong-Sup Kim, Moon Gyo Choi, Kyungho Choi, Eun Young Nat Commun Article Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8(+) T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60(+) hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors. Nature Publishing Group UK 2018-01-15 /pmc/articles/PMC5768767/ /pubmed/29335408 http://dx.doi.org/10.1038/s41467-017-02665-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ju, Ji-Min Jung, Min Ho Nam, Giri Kim, Woojin Oh, Sehwa Kim, Hyun Duk Kim, Joo Young Chang, Jun Lee, Sung Hak Park, Gyeong Sin Min, Chang-Ki Lee, Dong-Sup Kim, Moon Gyo Choi, Kyungho Choi, Eun Young Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title_full | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title_fullStr | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title_full_unstemmed | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title_short | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen |
title_sort | escape from thymic deletion and anti-leukemic effects of t cells specific for hematopoietic cell-restricted antigen |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768767/ https://www.ncbi.nlm.nih.gov/pubmed/29335408 http://dx.doi.org/10.1038/s41467-017-02665-z |
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