AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor clinical outcome, yet the underlying mechanisms remain unclear. Activation-induced cytidine deaminase (AICDA), an enzyme that me...

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Detalles Bibliográficos
Autores principales: Teater, Matt, Dominguez, Pilar M., Redmond, David, Chen, Zhengming, Ennishi, Daisuke, Scott, David W., Cimmino, Luisa, Ghione, Paola, Chaudhuri, Jayanta, Gascoyne, Randy D., Aifantis, Iannis, Inghirami, Giorgio, Elemento, Olivier, Melnick, Ari, Shaknovich, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768781/
https://www.ncbi.nlm.nih.gov/pubmed/29335468
http://dx.doi.org/10.1038/s41467-017-02595-w

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