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Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of the...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768785/ https://www.ncbi.nlm.nih.gov/pubmed/29335418 http://dx.doi.org/10.1038/s41598-017-18487-4 |
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author | Sasaki, Mariko Harada, Sei Kawasaki, Yumiko Watanabe, Miki Ito, Hidemi Tanaka, Hideo Takeuchi, Ayano Tsubota, Kazuo Takebayashi, Toru Nishiwaki, Yuji Kawasaki, Ryo |
author_facet | Sasaki, Mariko Harada, Sei Kawasaki, Yumiko Watanabe, Miki Ito, Hidemi Tanaka, Hideo Takeuchi, Ayano Tsubota, Kazuo Takebayashi, Toru Nishiwaki, Yuji Kawasaki, Ryo |
author_sort | Sasaki, Mariko |
collection | PubMed |
description | The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex. |
format | Online Article Text |
id | pubmed-5768785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57687852018-01-25 Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population Sasaki, Mariko Harada, Sei Kawasaki, Yumiko Watanabe, Miki Ito, Hidemi Tanaka, Hideo Takeuchi, Ayano Tsubota, Kazuo Takebayashi, Toru Nishiwaki, Yuji Kawasaki, Ryo Sci Rep Article The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex. Nature Publishing Group UK 2018-01-15 /pmc/articles/PMC5768785/ /pubmed/29335418 http://dx.doi.org/10.1038/s41598-017-18487-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sasaki, Mariko Harada, Sei Kawasaki, Yumiko Watanabe, Miki Ito, Hidemi Tanaka, Hideo Takeuchi, Ayano Tsubota, Kazuo Takebayashi, Toru Nishiwaki, Yuji Kawasaki, Ryo Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title | Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title_full | Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title_fullStr | Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title_full_unstemmed | Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title_short | Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
title_sort | gender-specific association of early age-related macular degeneration with systemic and genetic factors in a japanese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768785/ https://www.ncbi.nlm.nih.gov/pubmed/29335418 http://dx.doi.org/10.1038/s41598-017-18487-4 |
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