Cargando…

Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasaki, Mariko, Harada, Sei, Kawasaki, Yumiko, Watanabe, Miki, Ito, Hidemi, Tanaka, Hideo, Takeuchi, Ayano, Tsubota, Kazuo, Takebayashi, Toru, Nishiwaki, Yuji, Kawasaki, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768785/
https://www.ncbi.nlm.nih.gov/pubmed/29335418
http://dx.doi.org/10.1038/s41598-017-18487-4
_version_ 1783292772764090368
author Sasaki, Mariko
Harada, Sei
Kawasaki, Yumiko
Watanabe, Miki
Ito, Hidemi
Tanaka, Hideo
Takeuchi, Ayano
Tsubota, Kazuo
Takebayashi, Toru
Nishiwaki, Yuji
Kawasaki, Ryo
author_facet Sasaki, Mariko
Harada, Sei
Kawasaki, Yumiko
Watanabe, Miki
Ito, Hidemi
Tanaka, Hideo
Takeuchi, Ayano
Tsubota, Kazuo
Takebayashi, Toru
Nishiwaki, Yuji
Kawasaki, Ryo
author_sort Sasaki, Mariko
collection PubMed
description The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.
format Online
Article
Text
id pubmed-5768785
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-57687852018-01-25 Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population Sasaki, Mariko Harada, Sei Kawasaki, Yumiko Watanabe, Miki Ito, Hidemi Tanaka, Hideo Takeuchi, Ayano Tsubota, Kazuo Takebayashi, Toru Nishiwaki, Yuji Kawasaki, Ryo Sci Rep Article The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex. Nature Publishing Group UK 2018-01-15 /pmc/articles/PMC5768785/ /pubmed/29335418 http://dx.doi.org/10.1038/s41598-017-18487-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sasaki, Mariko
Harada, Sei
Kawasaki, Yumiko
Watanabe, Miki
Ito, Hidemi
Tanaka, Hideo
Takeuchi, Ayano
Tsubota, Kazuo
Takebayashi, Toru
Nishiwaki, Yuji
Kawasaki, Ryo
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title_full Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title_fullStr Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title_full_unstemmed Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title_short Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
title_sort gender-specific association of early age-related macular degeneration with systemic and genetic factors in a japanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768785/
https://www.ncbi.nlm.nih.gov/pubmed/29335418
http://dx.doi.org/10.1038/s41598-017-18487-4
work_keys_str_mv AT sasakimariko genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT haradasei genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT kawasakiyumiko genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT watanabemiki genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT itohidemi genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT tanakahideo genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT takeuchiayano genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT tsubotakazuo genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT takebayashitoru genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT nishiwakiyuji genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation
AT kawasakiryo genderspecificassociationofearlyagerelatedmaculardegenerationwithsystemicandgeneticfactorsinajapanesepopulation