A robust targeted sequencing approach for low input and variable quality DNA from clinical samples

Next-generation deep sequencing of gene panels is being adopted as a diagnostic test to identify actionable mutations in cancer patient samples. However, clinical samples, such as formalin-fixed, paraffin-embedded specimens, frequently provide low quantities of degraded, poor quality DNA. To overcom...

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Detalles Bibliográficos
Autores principales: So, Austin P., Vilborg, Anna, Bouhlal, Yosr, Koehler, Ryan T., Grimes, Susan M., Pouliot, Yannick, Mendoza, Daniel, Ziegle, Janet, Stein, Jason, Goodsaid, Federico, Lucero, Michael Y., De La Vega, Francisco M., Ji, Hanlee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768874/
https://www.ncbi.nlm.nih.gov/pubmed/29354287
http://dx.doi.org/10.1038/s41525-017-0041-4

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