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Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice

To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery. Exenatide was encapsulated into the NPs by the w/o/w emulsion-solvent evaporation method. The particle size of the NPs-Fc w...

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Detalles Bibliográficos
Autores principales:	Shi, Yanan, Sun, Xinfeng, Zhang, Liping, Sun, Kaoxiang, Li, Keke, Li, Youxin, Zhang, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768888/ https://www.ncbi.nlm.nih.gov/pubmed/29335533 http://dx.doi.org/10.1038/s41598-018-19170-y

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