Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFNγ) immunity and is characterized by severe infections by weakly virulent mycobacteria. Although IFNγ is the macrophage-activating factor, macrophages from these patients have never been studie...

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Detalles Bibliográficos
Autores principales: Neehus, Anna-Lena, Lam, Jenny, Haake, Kathrin, Merkert, Sylvia, Schmidt, Nico, Mucci, Adele, Ackermann, Mania, Schubert, Madline, Happle, Christine, Kühnel, Mark Philipp, Blank, Patrick, Philipp, Friederike, Goethe, Ralph, Jonigk, Danny, Martin, Ulrich, Kalinke, Ulrich, Baumann, Ulrich, Schambach, Axel, Roesler, Joachim, Lachmann, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768914/
https://www.ncbi.nlm.nih.gov/pubmed/29249666
http://dx.doi.org/10.1016/j.stemcr.2017.11.011

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