INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

AIM: To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis (NASH). METHODS: The effects of INT-767 on histological features of NASH were assessed in two studies using...

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Detalles Bibliográficos
Autores principales: Roth, Jonathan D, Feigh, Michael, Veidal, Sanne S, Fensholdt, Louise KD, Rigbolt, Kristoffer T, Hansen, Henrik H, Chen, Li C, Petitjean, Mathieu, Friley, Weslyn, Vrang, Niels, Jelsing, Jacob, Young, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768938/
https://www.ncbi.nlm.nih.gov/pubmed/29375205
http://dx.doi.org/10.3748/wjg.v24.i2.195

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