TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency

Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs). In mouse, ICR methylation and TE expression are each regulated by TRIM28; however, the role of TRIM28 in humans is less clea...

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Detalles Bibliográficos
Autores principales: Tao, Yu, Yen, Ming-Ren, Chitiashvili, Tsotne, Nakano, Haruko, Kim, Rachel, Hosohama, Linzi, Tan, Yao Chang, Nakano, Atsushi, Chen, Pao-Yang, Clark, Amander T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768987/
https://www.ncbi.nlm.nih.gov/pubmed/29290627
http://dx.doi.org/10.1016/j.stemcr.2017.11.020

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