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Impact of the histological phenotype of extrahepatic bile duct carcinoma

The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinic...

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Autores principales: Okano, Kensuke, Yoshizawa, Tadashi, Miura, Takuya, Ishido, Keinosuke, Kudo, Daisuke, Kimura, Norihisa, Wakiya, Tai-Ichi, Wu, Yunyan, Morohashi, Satoko, Hakamada, Kenichi, Kijima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769285/
https://www.ncbi.nlm.nih.gov/pubmed/29387397
http://dx.doi.org/10.3892/mco.2017.1472
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author Okano, Kensuke
Yoshizawa, Tadashi
Miura, Takuya
Ishido, Keinosuke
Kudo, Daisuke
Kimura, Norihisa
Wakiya, Tai-Ichi
Wu, Yunyan
Morohashi, Satoko
Hakamada, Kenichi
Kijima, Hiroshi
author_facet Okano, Kensuke
Yoshizawa, Tadashi
Miura, Takuya
Ishido, Keinosuke
Kudo, Daisuke
Kimura, Norihisa
Wakiya, Tai-Ichi
Wu, Yunyan
Morohashi, Satoko
Hakamada, Kenichi
Kijima, Hiroshi
author_sort Okano, Kensuke
collection PubMed
description The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinicopathological features of extrahepatic cholangiocarcinoma, using 99 cases of surgically-resected extrahepatic cholangiocarcinoma. All cases were divided into one of two histological phenotypes: Biliary-type (BT; 56 cases, 56.6%) or metaplastic-type (MT; 43 cases, 43.4%). The clinicopathological features were compared between these two phenotypes. BT tumors exhibited significantly poorer differentiation, more frequent lymph node metastasis (BT vs. MT, 42.9 vs. 30.2%; P=0.042), more severe venous invasion (v2-3: BT vs. MT, 64.3 vs. 23.3%; P<0.001), and more severe perineural invasion (ne2-3: BT vs. MT, 78.6 vs. 48.8%, P=0.002). Furthermore, the overall (P=0.015) and disease-free (P=0.003) survival times were significantly decreased in patients with BT vs. MT tumors. In conclusion, extrahepatic cholangiocarcinoma with a BT phenotype has greater malignant potential, and may be an important predictive factor for poor prognosis.
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spelling pubmed-57692852018-01-31 Impact of the histological phenotype of extrahepatic bile duct carcinoma Okano, Kensuke Yoshizawa, Tadashi Miura, Takuya Ishido, Keinosuke Kudo, Daisuke Kimura, Norihisa Wakiya, Tai-Ichi Wu, Yunyan Morohashi, Satoko Hakamada, Kenichi Kijima, Hiroshi Mol Clin Oncol Articles The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinicopathological features of extrahepatic cholangiocarcinoma, using 99 cases of surgically-resected extrahepatic cholangiocarcinoma. All cases were divided into one of two histological phenotypes: Biliary-type (BT; 56 cases, 56.6%) or metaplastic-type (MT; 43 cases, 43.4%). The clinicopathological features were compared between these two phenotypes. BT tumors exhibited significantly poorer differentiation, more frequent lymph node metastasis (BT vs. MT, 42.9 vs. 30.2%; P=0.042), more severe venous invasion (v2-3: BT vs. MT, 64.3 vs. 23.3%; P<0.001), and more severe perineural invasion (ne2-3: BT vs. MT, 78.6 vs. 48.8%, P=0.002). Furthermore, the overall (P=0.015) and disease-free (P=0.003) survival times were significantly decreased in patients with BT vs. MT tumors. In conclusion, extrahepatic cholangiocarcinoma with a BT phenotype has greater malignant potential, and may be an important predictive factor for poor prognosis. D.A. Spandidos 2018-01 2017-10-27 /pmc/articles/PMC5769285/ /pubmed/29387397 http://dx.doi.org/10.3892/mco.2017.1472 Text en Copyright: © Okano et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Okano, Kensuke
Yoshizawa, Tadashi
Miura, Takuya
Ishido, Keinosuke
Kudo, Daisuke
Kimura, Norihisa
Wakiya, Tai-Ichi
Wu, Yunyan
Morohashi, Satoko
Hakamada, Kenichi
Kijima, Hiroshi
Impact of the histological phenotype of extrahepatic bile duct carcinoma
title Impact of the histological phenotype of extrahepatic bile duct carcinoma
title_full Impact of the histological phenotype of extrahepatic bile duct carcinoma
title_fullStr Impact of the histological phenotype of extrahepatic bile duct carcinoma
title_full_unstemmed Impact of the histological phenotype of extrahepatic bile duct carcinoma
title_short Impact of the histological phenotype of extrahepatic bile duct carcinoma
title_sort impact of the histological phenotype of extrahepatic bile duct carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769285/
https://www.ncbi.nlm.nih.gov/pubmed/29387397
http://dx.doi.org/10.3892/mco.2017.1472
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