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Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep

BACKGROUND: Flaxseed is the most common and rich dietary source of lignans and is an acceptable supply of energy for livestock. Flaxseed lignans are precursors of enterolignans, mainly enterolactone and enterodiol, produced by the rumen and intestinal microbiota of mammals and have many important bi...

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Autores principales: Otero, Jon Andoni, García-Mateos, Dafne, Alvarez-Fernández, Indira, García-Villalba, Rocío, Espín, Juan Carlos, Álvarez, Ana Isabel, Merino, Gracia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769330/
https://www.ncbi.nlm.nih.gov/pubmed/29334949
http://dx.doi.org/10.1186/s12917-018-1341-3
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author Otero, Jon Andoni
García-Mateos, Dafne
Alvarez-Fernández, Indira
García-Villalba, Rocío
Espín, Juan Carlos
Álvarez, Ana Isabel
Merino, Gracia
author_facet Otero, Jon Andoni
García-Mateos, Dafne
Alvarez-Fernández, Indira
García-Villalba, Rocío
Espín, Juan Carlos
Álvarez, Ana Isabel
Merino, Gracia
author_sort Otero, Jon Andoni
collection PubMed
description BACKGROUND: Flaxseed is the most common and rich dietary source of lignans and is an acceptable supply of energy for livestock. Flaxseed lignans are precursors of enterolignans, mainly enterolactone and enterodiol, produced by the rumen and intestinal microbiota of mammals and have many important biological properties as phytoestrogens. Potential food-drug interactions involving flaxseed may be relevant for veterinary therapy, and for the quality and safety of milk and dairy products. Our aim was to investigate a potential food-drug interaction involving flaxseed, to explore whether the inclusion of flaxseed in sheep diet affects concentration of the antimicrobial danofloxacin in milk. RESULTS: Increased concentrations of enterodiol and enterolactone were observed in sheep plasma and milk after 2 weeks of flaxseed supplementation (P < 0.05). However, enterolactone and enterodiol conjugates were not detected in milk. Milk danofloxacin pharmacokinetics showed that area under the curve (AUC)(0–24,) maximum concentration (C(max)) and AUC(0–24) milk-to-plasma ratios were reduced by 25–30% in sheep fed flaxseed-enriched diets (P < 0.05). Our results demonstrate, therefore, that flaxseed-enriched diets reduce the amount of danofloxacin in sheep milk and enrich the milk content of lignan-derivatives. CONCLUSION: These findings highlight an effect of flaxseed-enriched diets on the concentration of antimicrobials in ruminant’s milk, revealing the potential of these modified diets for the control of residues of antimicrobial drugs in milk.
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spelling pubmed-57693302018-01-25 Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep Otero, Jon Andoni García-Mateos, Dafne Alvarez-Fernández, Indira García-Villalba, Rocío Espín, Juan Carlos Álvarez, Ana Isabel Merino, Gracia BMC Vet Res Research Article BACKGROUND: Flaxseed is the most common and rich dietary source of lignans and is an acceptable supply of energy for livestock. Flaxseed lignans are precursors of enterolignans, mainly enterolactone and enterodiol, produced by the rumen and intestinal microbiota of mammals and have many important biological properties as phytoestrogens. Potential food-drug interactions involving flaxseed may be relevant for veterinary therapy, and for the quality and safety of milk and dairy products. Our aim was to investigate a potential food-drug interaction involving flaxseed, to explore whether the inclusion of flaxseed in sheep diet affects concentration of the antimicrobial danofloxacin in milk. RESULTS: Increased concentrations of enterodiol and enterolactone were observed in sheep plasma and milk after 2 weeks of flaxseed supplementation (P < 0.05). However, enterolactone and enterodiol conjugates were not detected in milk. Milk danofloxacin pharmacokinetics showed that area under the curve (AUC)(0–24,) maximum concentration (C(max)) and AUC(0–24) milk-to-plasma ratios were reduced by 25–30% in sheep fed flaxseed-enriched diets (P < 0.05). Our results demonstrate, therefore, that flaxseed-enriched diets reduce the amount of danofloxacin in sheep milk and enrich the milk content of lignan-derivatives. CONCLUSION: These findings highlight an effect of flaxseed-enriched diets on the concentration of antimicrobials in ruminant’s milk, revealing the potential of these modified diets for the control of residues of antimicrobial drugs in milk. BioMed Central 2018-01-15 /pmc/articles/PMC5769330/ /pubmed/29334949 http://dx.doi.org/10.1186/s12917-018-1341-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Otero, Jon Andoni
García-Mateos, Dafne
Alvarez-Fernández, Indira
García-Villalba, Rocío
Espín, Juan Carlos
Álvarez, Ana Isabel
Merino, Gracia
Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title_full Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title_fullStr Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title_full_unstemmed Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title_short Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
title_sort flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769330/
https://www.ncbi.nlm.nih.gov/pubmed/29334949
http://dx.doi.org/10.1186/s12917-018-1341-3
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