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High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma

The present study was undertaken to explore the association between the expression of hepatocyte growth factor receptor (c-Met) and epidermal growth factor receptor (EGFR) with clinicopathological factors and survival status, to obtain prognostic biomarkers in patients with glottis laryngeal squamou...

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Autores principales: Jiang, Mei, Zhang, Hui, Xiao, He, Zhang, Zhimin, Que, Dan, Luo, Jia, Li, Jian, Mao, Bijing, Chen, Yuanyuan, Lan, Meilin, Wang, Ge, Xiao, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769407/
https://www.ncbi.nlm.nih.gov/pubmed/29391895
http://dx.doi.org/10.3892/ol.2017.7356
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author Jiang, Mei
Zhang, Hui
Xiao, He
Zhang, Zhimin
Que, Dan
Luo, Jia
Li, Jian
Mao, Bijing
Chen, Yuanyuan
Lan, Meilin
Wang, Ge
Xiao, Hualiang
author_facet Jiang, Mei
Zhang, Hui
Xiao, He
Zhang, Zhimin
Que, Dan
Luo, Jia
Li, Jian
Mao, Bijing
Chen, Yuanyuan
Lan, Meilin
Wang, Ge
Xiao, Hualiang
author_sort Jiang, Mei
collection PubMed
description The present study was undertaken to explore the association between the expression of hepatocyte growth factor receptor (c-Met) and epidermal growth factor receptor (EGFR) with clinicopathological factors and survival status, to obtain prognostic biomarkers in patients with glottis laryngeal squamous cell carcinoma (GLSCC). The expression status of c-Met and EGFR protein was analyzed in 71 archival laryngeal cancer samples by immunohistochemistry. Statistical methods, including univariate and multivariate Cox regression analysis, were used to determine risk factors of progression. In addition, survival analysis was performed by the Kaplan-Meier method. The present study detected positive expression of c-Met and EGFR in 69.0 and 91.5% of GLSCC samples, respectively. The median disease-free survival (DFS) and overall survival (OS) times of all patients were 42.4 and 81.8 months, respectively, and the 2-year DFS and OS rates were 60.1 and 84.91%, respectively. Univariate Cox regression analysis revealed that patients with high expression of EGFR or c-Met had a predisposition for tumor recurrence. The expression of c-Met expression was significantly associated with that of EGFR (P=0.001). High expression of c-Met or EGFR was associated with shorter DFS and OS times. Findings of the multivariate Cox regression analysis indicated that c-Met-expression may be used as an independent predictor of DFS and OS (P=0.002 and P=0.008, respectively). However, EGFR expression was not an independent predictor for DFS and OS (P=0.352 and P=0.24, respectively). The high expression of c-Met and EGFR was associated with poor survival and are important predictors for prognosis of patients with GLSCC.
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spelling pubmed-57694072018-02-01 High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma Jiang, Mei Zhang, Hui Xiao, He Zhang, Zhimin Que, Dan Luo, Jia Li, Jian Mao, Bijing Chen, Yuanyuan Lan, Meilin Wang, Ge Xiao, Hualiang Oncol Lett Articles The present study was undertaken to explore the association between the expression of hepatocyte growth factor receptor (c-Met) and epidermal growth factor receptor (EGFR) with clinicopathological factors and survival status, to obtain prognostic biomarkers in patients with glottis laryngeal squamous cell carcinoma (GLSCC). The expression status of c-Met and EGFR protein was analyzed in 71 archival laryngeal cancer samples by immunohistochemistry. Statistical methods, including univariate and multivariate Cox regression analysis, were used to determine risk factors of progression. In addition, survival analysis was performed by the Kaplan-Meier method. The present study detected positive expression of c-Met and EGFR in 69.0 and 91.5% of GLSCC samples, respectively. The median disease-free survival (DFS) and overall survival (OS) times of all patients were 42.4 and 81.8 months, respectively, and the 2-year DFS and OS rates were 60.1 and 84.91%, respectively. Univariate Cox regression analysis revealed that patients with high expression of EGFR or c-Met had a predisposition for tumor recurrence. The expression of c-Met expression was significantly associated with that of EGFR (P=0.001). High expression of c-Met or EGFR was associated with shorter DFS and OS times. Findings of the multivariate Cox regression analysis indicated that c-Met-expression may be used as an independent predictor of DFS and OS (P=0.002 and P=0.008, respectively). However, EGFR expression was not an independent predictor for DFS and OS (P=0.352 and P=0.24, respectively). The high expression of c-Met and EGFR was associated with poor survival and are important predictors for prognosis of patients with GLSCC. D.A. Spandidos 2018-01 2017-11-08 /pmc/articles/PMC5769407/ /pubmed/29391895 http://dx.doi.org/10.3892/ol.2017.7356 Text en Copyright: © Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Jiang, Mei
Zhang, Hui
Xiao, He
Zhang, Zhimin
Que, Dan
Luo, Jia
Li, Jian
Mao, Bijing
Chen, Yuanyuan
Lan, Meilin
Wang, Ge
Xiao, Hualiang
High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title_full High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title_fullStr High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title_full_unstemmed High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title_short High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
title_sort high expression of c-met and egfr is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769407/
https://www.ncbi.nlm.nih.gov/pubmed/29391895
http://dx.doi.org/10.3892/ol.2017.7356
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