Cargando…

Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diamete...

Descripción completa

Detalles Bibliográficos
Autores principales: Kutty, Shelby, Liu, Na, Zhou, Jia, Xiao, Yunbin, Wu, Juefei, Danford, David A., Lof, John, Xie, Feng, Porter, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769697/
https://www.ncbi.nlm.nih.gov/pubmed/29349360
http://dx.doi.org/10.1016/j.jacbts.2017.07.011
_version_ 1783292943813050368
author Kutty, Shelby
Liu, Na
Zhou, Jia
Xiao, Yunbin
Wu, Juefei
Danford, David A.
Lof, John
Xie, Feng
Porter, Thomas R.
author_facet Kutty, Shelby
Liu, Na
Zhou, Jia
Xiao, Yunbin
Wu, Juefei
Danford, David A.
Lof, John
Xie, Feng
Porter, Thomas R.
author_sort Kutty, Shelby
collection PubMed
description Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.
format Online
Article
Text
id pubmed-5769697
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-57696972018-01-16 Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm Kutty, Shelby Liu, Na Zhou, Jia Xiao, Yunbin Wu, Juefei Danford, David A. Lof, John Xie, Feng Porter, Thomas R. JACC Basic Transl Sci PRECLINICAL RESEARCH Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available. Elsevier 2017-11-15 /pmc/articles/PMC5769697/ /pubmed/29349360 http://dx.doi.org/10.1016/j.jacbts.2017.07.011 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Kutty, Shelby
Liu, Na
Zhou, Jia
Xiao, Yunbin
Wu, Juefei
Danford, David A.
Lof, John
Xie, Feng
Porter, Thomas R.
Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title_full Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title_fullStr Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title_full_unstemmed Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title_short Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
title_sort ultrasound-induced microbubble cavitation for the treatment of catheterization-induced vasospasm
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769697/
https://www.ncbi.nlm.nih.gov/pubmed/29349360
http://dx.doi.org/10.1016/j.jacbts.2017.07.011
work_keys_str_mv AT kuttyshelby ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT liuna ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT zhoujia ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT xiaoyunbin ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT wujuefei ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT danforddavida ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT lofjohn ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT xiefeng ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm
AT porterthomasr ultrasoundinducedmicrobubblecavitationforthetreatmentofcatheterizationinducedvasospasm