Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis

Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222–2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Sump, Bethany, Brickner, Jason H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769765/
https://www.ncbi.nlm.nih.gov/pubmed/29284709
http://dx.doi.org/10.1101/gad.310359.117
_version_ 1783292956812247040
author Sump, Bethany
Brickner, Jason H.
author_facet Sump, Bethany
Brickner, Jason H.
author_sort Sump, Bethany
collection PubMed
description Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222–2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.
format Online
Article
Text
id pubmed-5769765
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-57697652018-05-15 Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis Sump, Bethany Brickner, Jason H. Genes Dev Outlook Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222–2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia. Cold Spring Harbor Laboratory Press 2017-11-15 /pmc/articles/PMC5769765/ /pubmed/29284709 http://dx.doi.org/10.1101/gad.310359.117 Text en © 2017 Sump and Brickner; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Sump, Bethany
Brickner, Jason H.
Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title_full Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title_fullStr Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title_full_unstemmed Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title_short Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
title_sort nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769765/
https://www.ncbi.nlm.nih.gov/pubmed/29284709
http://dx.doi.org/10.1101/gad.310359.117
work_keys_str_mv AT sumpbethany nup98regulationofhistonemethylationpromotesnormalgeneexpressionandmaydriveleukemogenesis
AT bricknerjasonh nup98regulationofhistonemethylationpromotesnormalgeneexpressionandmaydriveleukemogenesis

Ejemplares similares