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CD4 and CD8 T lymphocyte interplay in controlling tumor growth
The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both population...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769828/ https://www.ncbi.nlm.nih.gov/pubmed/29032503 http://dx.doi.org/10.1007/s00018-017-2686-7 |
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author | Ostroumov, Dmitrij Fekete-Drimusz, Nora Saborowski, Michael Kühnel, Florian Woller, Norman |
author_facet | Ostroumov, Dmitrij Fekete-Drimusz, Nora Saborowski, Michael Kühnel, Florian Woller, Norman |
author_sort | Ostroumov, Dmitrij |
collection | PubMed |
description | The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to protect the host against cancer. Each of them has to be undermined or evaded during cancer development to enable tumor outgrowth. In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies. The main focus is on the currently existing knowledge about the CD4 and CD8 T lymphocyte interplay that mediates the control of tumor growth. |
format | Online Article Text |
id | pubmed-5769828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57698282018-01-29 CD4 and CD8 T lymphocyte interplay in controlling tumor growth Ostroumov, Dmitrij Fekete-Drimusz, Nora Saborowski, Michael Kühnel, Florian Woller, Norman Cell Mol Life Sci Review The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to protect the host against cancer. Each of them has to be undermined or evaded during cancer development to enable tumor outgrowth. In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies. The main focus is on the currently existing knowledge about the CD4 and CD8 T lymphocyte interplay that mediates the control of tumor growth. Springer International Publishing 2017-10-14 2018 /pmc/articles/PMC5769828/ /pubmed/29032503 http://dx.doi.org/10.1007/s00018-017-2686-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Ostroumov, Dmitrij Fekete-Drimusz, Nora Saborowski, Michael Kühnel, Florian Woller, Norman CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title | CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title_full | CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title_fullStr | CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title_full_unstemmed | CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title_short | CD4 and CD8 T lymphocyte interplay in controlling tumor growth |
title_sort | cd4 and cd8 t lymphocyte interplay in controlling tumor growth |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769828/ https://www.ncbi.nlm.nih.gov/pubmed/29032503 http://dx.doi.org/10.1007/s00018-017-2686-7 |
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