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CD4 and CD8 T lymphocyte interplay in controlling tumor growth

The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both population...

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Autores principales: Ostroumov, Dmitrij, Fekete-Drimusz, Nora, Saborowski, Michael, Kühnel, Florian, Woller, Norman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769828/
https://www.ncbi.nlm.nih.gov/pubmed/29032503
http://dx.doi.org/10.1007/s00018-017-2686-7
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author Ostroumov, Dmitrij
Fekete-Drimusz, Nora
Saborowski, Michael
Kühnel, Florian
Woller, Norman
author_facet Ostroumov, Dmitrij
Fekete-Drimusz, Nora
Saborowski, Michael
Kühnel, Florian
Woller, Norman
author_sort Ostroumov, Dmitrij
collection PubMed
description The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to protect the host against cancer. Each of them has to be undermined or evaded during cancer development to enable tumor outgrowth. In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies. The main focus is on the currently existing knowledge about the CD4 and CD8 T lymphocyte interplay that mediates the control of tumor growth.
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spelling pubmed-57698282018-01-29 CD4 and CD8 T lymphocyte interplay in controlling tumor growth Ostroumov, Dmitrij Fekete-Drimusz, Nora Saborowski, Michael Kühnel, Florian Woller, Norman Cell Mol Life Sci Review The outstanding clinical success of immune checkpoint blockade has revived the interest in underlying mechanisms of the immune system that are capable of eliminating tumors even in advanced stages. In this scenario, CD4 and CD8 T cell responses are part of the cancer immune cycle and both populations significantly influence the clinical outcome. In general, the immune system has evolved several mechanisms to protect the host against cancer. Each of them has to be undermined or evaded during cancer development to enable tumor outgrowth. In this review, we give an overview of T lymphocyte-driven control of tumor growth and discuss the involved tumor-suppressive mechanisms of the immune system, such as senescence surveillance, cancer immunosurveillance, and cancer immunoediting with respect to recent clinical developments of immunotherapies. The main focus is on the currently existing knowledge about the CD4 and CD8 T lymphocyte interplay that mediates the control of tumor growth. Springer International Publishing 2017-10-14 2018 /pmc/articles/PMC5769828/ /pubmed/29032503 http://dx.doi.org/10.1007/s00018-017-2686-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Ostroumov, Dmitrij
Fekete-Drimusz, Nora
Saborowski, Michael
Kühnel, Florian
Woller, Norman
CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title_full CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title_fullStr CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title_full_unstemmed CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title_short CD4 and CD8 T lymphocyte interplay in controlling tumor growth
title_sort cd4 and cd8 t lymphocyte interplay in controlling tumor growth
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769828/
https://www.ncbi.nlm.nih.gov/pubmed/29032503
http://dx.doi.org/10.1007/s00018-017-2686-7
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