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Neuroimaging in cerebral small vessel disease: Update and new concepts
In recent years, small vessel disease (SVD) has been recognized for its major impact on cognitive impairment in elderly people, where it is often difficult to separate its effects from those of neurodegenerative diseases individually. SVD is a systemic disease, probably related to diffuse endothelia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do Comportamento
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769991/ https://www.ncbi.nlm.nih.gov/pubmed/29354213 http://dx.doi.org/10.1590/1980-57642016dn11-040002 |
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author | Shibuya, Mika Leite, Claudia da Costa Lucato, Leandro Tavares |
author_facet | Shibuya, Mika Leite, Claudia da Costa Lucato, Leandro Tavares |
author_sort | Shibuya, Mika |
collection | PubMed |
description | In recent years, small vessel disease (SVD) has been recognized for its major impact on cognitive impairment in elderly people, where it is often difficult to separate its effects from those of neurodegenerative diseases individually. SVD is a systemic disease, probably related to diffuse endothelial dysfunction, which affects the perforating arterioles, capillaries and venules in the brain. Although often asymptomatic, it is responsible for almost half of all dementia cases and a significant proportion of stroke cases. Imaging features found on magnetic resonance include recent small subcortical infarctions, lacunes of presumed vascular origin, white matter hyperintensity of presumed vascular origin, prominent perivascular spaces and cerebral microbleeds. The recognition of these imaging findings as a spectrum of the same disease caused by endothelial dysfunction of small cerebral vessels can allow an overall analysis of the disease and thus the development of more effective preventive and therapeutic strategies. |
format | Online Article Text |
id | pubmed-5769991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Associação de Neurologia Cognitiva e do Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-57699912018-01-19 Neuroimaging in cerebral small vessel disease: Update and new concepts Shibuya, Mika Leite, Claudia da Costa Lucato, Leandro Tavares Dement Neuropsychol Views & Reviews In recent years, small vessel disease (SVD) has been recognized for its major impact on cognitive impairment in elderly people, where it is often difficult to separate its effects from those of neurodegenerative diseases individually. SVD is a systemic disease, probably related to diffuse endothelial dysfunction, which affects the perforating arterioles, capillaries and venules in the brain. Although often asymptomatic, it is responsible for almost half of all dementia cases and a significant proportion of stroke cases. Imaging features found on magnetic resonance include recent small subcortical infarctions, lacunes of presumed vascular origin, white matter hyperintensity of presumed vascular origin, prominent perivascular spaces and cerebral microbleeds. The recognition of these imaging findings as a spectrum of the same disease caused by endothelial dysfunction of small cerebral vessels can allow an overall analysis of the disease and thus the development of more effective preventive and therapeutic strategies. Associação de Neurologia Cognitiva e do Comportamento 2017 /pmc/articles/PMC5769991/ /pubmed/29354213 http://dx.doi.org/10.1590/1980-57642016dn11-040002 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Views & Reviews Shibuya, Mika Leite, Claudia da Costa Lucato, Leandro Tavares Neuroimaging in cerebral small vessel disease: Update and new concepts |
title | Neuroimaging in cerebral small vessel disease: Update and new concepts |
title_full | Neuroimaging in cerebral small vessel disease: Update and new concepts |
title_fullStr | Neuroimaging in cerebral small vessel disease: Update and new concepts |
title_full_unstemmed | Neuroimaging in cerebral small vessel disease: Update and new concepts |
title_short | Neuroimaging in cerebral small vessel disease: Update and new concepts |
title_sort | neuroimaging in cerebral small vessel disease: update and new concepts |
topic | Views & Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769991/ https://www.ncbi.nlm.nih.gov/pubmed/29354213 http://dx.doi.org/10.1590/1980-57642016dn11-040002 |
work_keys_str_mv | AT shibuyamika neuroimagingincerebralsmallvesseldiseaseupdateandnewconcepts AT leiteclaudiadacosta neuroimagingincerebralsmallvesseldiseaseupdateandnewconcepts AT lucatoleandrotavares neuroimagingincerebralsmallvesseldiseaseupdateandnewconcepts |