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A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis

BACKGROUND. Subcortical Vascular Cognitive Impairment (SVCI) is a clinical continuum of vascular-related cognitive impairment, including Vascular Mild Cognitive Impairment (VaMCI) and Vascular Dementia. Deficits in Executive Function (EF) are hallmarks of the disorder, but the best methods to assess...

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Autores principales: Sudo, Felipe Kenji, Amado, Patricia, Alves, Gilberto Sousa, Laks, Jerson, Engelhardt, Eliasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769995/
https://www.ncbi.nlm.nih.gov/pubmed/29354217
http://dx.doi.org/10.1590/1980-57642016dn11-040006
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author Sudo, Felipe Kenji
Amado, Patricia
Alves, Gilberto Sousa
Laks, Jerson
Engelhardt, Eliasz
author_facet Sudo, Felipe Kenji
Amado, Patricia
Alves, Gilberto Sousa
Laks, Jerson
Engelhardt, Eliasz
author_sort Sudo, Felipe Kenji
collection PubMed
description BACKGROUND. Subcortical Vascular Cognitive Impairment (SVCI) is a clinical continuum of vascular-related cognitive impairment, including Vascular Mild Cognitive Impairment (VaMCI) and Vascular Dementia. Deficits in Executive Function (EF) are hallmarks of the disorder, but the best methods to assess this function have yet to be determined. The insidious and almost predictable course of SVCI and the multidimensional concept of EF suggest that a temporal dissociation of impairments in EF domains exists early in the disorder. OBJECTIVE: This study aims to review and analyze data from the literature about performance of VaMCI patients on the most used EF tests through a meta-analytic approach. METHODS: Medline, Web of Knowledge and PsycINFO were searched, using the terms: “vascular mild cognitive impairment” OR “vascular cognitive impairment no dementia” OR “vascular mild neurocognitive disorder” AND “dysexecutive” OR “executive function”. Meta-analyses were conducted for each of the selected tests, using random-effect models. RESULTS: Systematic review showed major discrepancies among the results of the studies included. Meta-analyses evidenced poorer performance on the Trail-Making Test part B and the Stroop color test by VaMCI patients compared to controls. CONCLUSION: A continuum of EF impairments has been proposed in SVCI. Early deficits appear to occur in cognitive flexibility and inhibitory control.
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spelling pubmed-57699952018-01-19 A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis Sudo, Felipe Kenji Amado, Patricia Alves, Gilberto Sousa Laks, Jerson Engelhardt, Eliasz Dement Neuropsychol Views & Reviews BACKGROUND. Subcortical Vascular Cognitive Impairment (SVCI) is a clinical continuum of vascular-related cognitive impairment, including Vascular Mild Cognitive Impairment (VaMCI) and Vascular Dementia. Deficits in Executive Function (EF) are hallmarks of the disorder, but the best methods to assess this function have yet to be determined. The insidious and almost predictable course of SVCI and the multidimensional concept of EF suggest that a temporal dissociation of impairments in EF domains exists early in the disorder. OBJECTIVE: This study aims to review and analyze data from the literature about performance of VaMCI patients on the most used EF tests through a meta-analytic approach. METHODS: Medline, Web of Knowledge and PsycINFO were searched, using the terms: “vascular mild cognitive impairment” OR “vascular cognitive impairment no dementia” OR “vascular mild neurocognitive disorder” AND “dysexecutive” OR “executive function”. Meta-analyses were conducted for each of the selected tests, using random-effect models. RESULTS: Systematic review showed major discrepancies among the results of the studies included. Meta-analyses evidenced poorer performance on the Trail-Making Test part B and the Stroop color test by VaMCI patients compared to controls. CONCLUSION: A continuum of EF impairments has been proposed in SVCI. Early deficits appear to occur in cognitive flexibility and inhibitory control. Associação de Neurologia Cognitiva e do Comportamento 2017 /pmc/articles/PMC5769995/ /pubmed/29354217 http://dx.doi.org/10.1590/1980-57642016dn11-040006 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Views & Reviews
Sudo, Felipe Kenji
Amado, Patricia
Alves, Gilberto Sousa
Laks, Jerson
Engelhardt, Eliasz
A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title_full A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title_fullStr A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title_full_unstemmed A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title_short A continuum of executive function deficits in early subcortical vascular cognitive impairment: A systematic review and meta-analysis
title_sort continuum of executive function deficits in early subcortical vascular cognitive impairment: a systematic review and meta-analysis
topic Views & Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769995/
https://www.ncbi.nlm.nih.gov/pubmed/29354217
http://dx.doi.org/10.1590/1980-57642016dn11-040006
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