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Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance

Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. OBJECTIVE: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hyperte...

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Autores principales: Muela, Henrique Cotchi Simbo, Costa-Hong, Valeria A., Yassuda, Monica Sanches, Machado, Michel Ferreira, Nogueira, Ricardo de Carvalho, Moraes, Natalia C., Memória, Claudia Maia, Macedo, Thiago A., Bor-Seng-Shu, Edson, Massaro, Ayrton Roberto, Nitrini, Ricardo, Bortolotto, Luiz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769997/
https://www.ncbi.nlm.nih.gov/pubmed/29354219
http://dx.doi.org/10.1590/1980-57642016dn11-040008
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author Muela, Henrique Cotchi Simbo
Costa-Hong, Valeria A.
Yassuda, Monica Sanches
Machado, Michel Ferreira
Nogueira, Ricardo de Carvalho
Moraes, Natalia C.
Memória, Claudia Maia
Macedo, Thiago A.
Bor-Seng-Shu, Edson
Massaro, Ayrton Roberto
Nitrini, Ricardo
Bortolotto, Luiz A.
author_facet Muela, Henrique Cotchi Simbo
Costa-Hong, Valeria A.
Yassuda, Monica Sanches
Machado, Michel Ferreira
Nogueira, Ricardo de Carvalho
Moraes, Natalia C.
Memória, Claudia Maia
Macedo, Thiago A.
Bor-Seng-Shu, Edson
Massaro, Ayrton Roberto
Nitrini, Ricardo
Bortolotto, Luiz A.
author_sort Muela, Henrique Cotchi Simbo
collection PubMed
description Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. OBJECTIVE: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension. METHODS: 211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological (NPE) tests were used to determine cognitive function. Pulse wave velocity was measured using the Complior(®). Carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. Middle cerebral artery flow velocity was measured by transcranial Doppler ultrasonography. RESULTS: Both arterial stiffness parameters and cerebral vasoreactivity worsened in line with HTN severity. There was a negative correlation between breath holding index (BHI) and arterial stiffness parameters. Cognitive performance worsened in line with HTN severity, with statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE and MoCA. The same tendency was observed on the NPE tests. CONCLUSION: Hypertension severity was associated with higher AS, worse BHI, and lower cognitive performance.
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spelling pubmed-57699972018-01-19 Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance Muela, Henrique Cotchi Simbo Costa-Hong, Valeria A. Yassuda, Monica Sanches Machado, Michel Ferreira Nogueira, Ricardo de Carvalho Moraes, Natalia C. Memória, Claudia Maia Macedo, Thiago A. Bor-Seng-Shu, Edson Massaro, Ayrton Roberto Nitrini, Ricardo Bortolotto, Luiz A. Dement Neuropsychol Original Article Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural and functional changes of the arterial wall. OBJECTIVE: To evaluate whether arterial stiffness (AS) is related to cerebral blood flow changes and its association with cognitive function in patients with hypertension. METHODS: 211 patients (69 normotensive and 142 hypertensive) were included. Patients with hypertension were divided into 2 stages: HTN stage-1 and HTN stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological (NPE) tests were used to determine cognitive function. Pulse wave velocity was measured using the Complior(®). Carotid properties were assessed by radiofrequency ultrasound. Central arterial pressure and augmentation index were obtained using applanation tonometry. Middle cerebral artery flow velocity was measured by transcranial Doppler ultrasonography. RESULTS: Both arterial stiffness parameters and cerebral vasoreactivity worsened in line with HTN severity. There was a negative correlation between breath holding index (BHI) and arterial stiffness parameters. Cognitive performance worsened in line with HTN severity, with statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE and MoCA. The same tendency was observed on the NPE tests. CONCLUSION: Hypertension severity was associated with higher AS, worse BHI, and lower cognitive performance. Associação de Neurologia Cognitiva e do Comportamento 2017 /pmc/articles/PMC5769997/ /pubmed/29354219 http://dx.doi.org/10.1590/1980-57642016dn11-040008 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Muela, Henrique Cotchi Simbo
Costa-Hong, Valeria A.
Yassuda, Monica Sanches
Machado, Michel Ferreira
Nogueira, Ricardo de Carvalho
Moraes, Natalia C.
Memória, Claudia Maia
Macedo, Thiago A.
Bor-Seng-Shu, Edson
Massaro, Ayrton Roberto
Nitrini, Ricardo
Bortolotto, Luiz A.
Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title_full Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title_fullStr Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title_full_unstemmed Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title_short Impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
title_sort impact of hypertension severity on arterial stiffness, cerebral vasoreactivity, and cognitive performance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769997/
https://www.ncbi.nlm.nih.gov/pubmed/29354219
http://dx.doi.org/10.1590/1980-57642016dn11-040008
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