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Cardiovascular risk factors and cognitive performance in aging
BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influenc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do Comportamento
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770004/ https://www.ncbi.nlm.nih.gov/pubmed/29354226 http://dx.doi.org/10.1590/1980-57642016dn11-040015 |
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author | Takeda, Juliana Rumy Tsuchihashi Matos, Tatiane Martins de Souza-Talarico, Juliana Nery |
author_facet | Takeda, Juliana Rumy Tsuchihashi Matos, Tatiane Martins de Souza-Talarico, Juliana Nery |
author_sort | Takeda, Juliana Rumy Tsuchihashi |
collection | PubMed |
description | BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. METHODS: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. RESULTS: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. CONCLUSION: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging. |
format | Online Article Text |
id | pubmed-5770004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Associação de Neurologia Cognitiva e do Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-57700042018-01-19 Cardiovascular risk factors and cognitive performance in aging Takeda, Juliana Rumy Tsuchihashi Matos, Tatiane Martins de Souza-Talarico, Juliana Nery Dement Neuropsychol Original Article BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. METHODS: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. RESULTS: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. CONCLUSION: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging. Associação de Neurologia Cognitiva e do Comportamento 2017 /pmc/articles/PMC5770004/ /pubmed/29354226 http://dx.doi.org/10.1590/1980-57642016dn11-040015 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Takeda, Juliana Rumy Tsuchihashi Matos, Tatiane Martins de Souza-Talarico, Juliana Nery Cardiovascular risk factors and cognitive performance in aging |
title | Cardiovascular risk factors and cognitive performance in aging |
title_full | Cardiovascular risk factors and cognitive performance in aging |
title_fullStr | Cardiovascular risk factors and cognitive performance in aging |
title_full_unstemmed | Cardiovascular risk factors and cognitive performance in aging |
title_short | Cardiovascular risk factors and cognitive performance in aging |
title_sort | cardiovascular risk factors and cognitive performance in aging |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770004/ https://www.ncbi.nlm.nih.gov/pubmed/29354226 http://dx.doi.org/10.1590/1980-57642016dn11-040015 |
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