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Cardiovascular risk factors and cognitive performance in aging

BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influenc...

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Autores principales: Takeda, Juliana Rumy Tsuchihashi, Matos, Tatiane Martins, de Souza-Talarico, Juliana Nery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770004/
https://www.ncbi.nlm.nih.gov/pubmed/29354226
http://dx.doi.org/10.1590/1980-57642016dn11-040015
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author Takeda, Juliana Rumy Tsuchihashi
Matos, Tatiane Martins
de Souza-Talarico, Juliana Nery
author_facet Takeda, Juliana Rumy Tsuchihashi
Matos, Tatiane Martins
de Souza-Talarico, Juliana Nery
author_sort Takeda, Juliana Rumy Tsuchihashi
collection PubMed
description BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. METHODS: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. RESULTS: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. CONCLUSION: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging.
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spelling pubmed-57700042018-01-19 Cardiovascular risk factors and cognitive performance in aging Takeda, Juliana Rumy Tsuchihashi Matos, Tatiane Martins de Souza-Talarico, Juliana Nery Dement Neuropsychol Original Article BACKGROUND. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. OBJECTIVE: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. METHODS: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. RESULTS: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. CONCLUSION: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging. Associação de Neurologia Cognitiva e do Comportamento 2017 /pmc/articles/PMC5770004/ /pubmed/29354226 http://dx.doi.org/10.1590/1980-57642016dn11-040015 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Takeda, Juliana Rumy Tsuchihashi
Matos, Tatiane Martins
de Souza-Talarico, Juliana Nery
Cardiovascular risk factors and cognitive performance in aging
title Cardiovascular risk factors and cognitive performance in aging
title_full Cardiovascular risk factors and cognitive performance in aging
title_fullStr Cardiovascular risk factors and cognitive performance in aging
title_full_unstemmed Cardiovascular risk factors and cognitive performance in aging
title_short Cardiovascular risk factors and cognitive performance in aging
title_sort cardiovascular risk factors and cognitive performance in aging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770004/
https://www.ncbi.nlm.nih.gov/pubmed/29354226
http://dx.doi.org/10.1590/1980-57642016dn11-040015
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