The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of these variants for primary infections are unknow...

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Detalles Bibliográficos
Autores principales: Ruiz-Moreno, Juan S., Hamann, Lutz, Shah, Javeed A., Verbon, Annelies, Mockenhaupt, Frank P., Puzianowska-Kuznicka, Monika, Naujoks, Jan, Sander, Leif E., Witzenrath, Martin, Cambier, John C., Suttorp, Norbert, Schumann, Ralf R., Jin, Lei, Hawn, Thomas R., Opitz, Bastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770077/
https://www.ncbi.nlm.nih.gov/pubmed/29298342
http://dx.doi.org/10.1371/journal.ppat.1006829

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