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From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis

Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in s...

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Detalles Bibliográficos
Autores principales:	Mardente, Stefania, Mari, Emanuela, Massimi, Isabella, Tafani, Marco, Guerriero, Raffaella, Morsilli, Ornella, Pulcinelli, Fabio M., Bianchi, Marco E., Zicari, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770369/ https://www.ncbi.nlm.nih.gov/pubmed/29375570 http://dx.doi.org/10.3389/fimmu.2017.01946

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