Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

Prolonged glucocorticoid (GC) therapy can cause GC-induced ocular hypertension (OHT), which if left untreated progresses to iatrogenic glaucoma and permanent vision loss. The alternatively spliced isoform of glucocorticoid receptor GRβ acts as dominant negative regulator of GR activity, and it has b...

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Detalles Bibliográficos
Autores principales: Patel, Gaurang C., Liu, Yang, Millar, J. Cameron, Clark, Abbot F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770444/
https://www.ncbi.nlm.nih.gov/pubmed/29339763
http://dx.doi.org/10.1038/s41598-018-19262-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770444/
https://www.ncbi.nlm.nih.gov/pubmed/29339763
http://dx.doi.org/10.1038/s41598-018-19262-9

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