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Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice
Prolonged glucocorticoid (GC) therapy can cause GC-induced ocular hypertension (OHT), which if left untreated progresses to iatrogenic glaucoma and permanent vision loss. The alternatively spliced isoform of glucocorticoid receptor GRβ acts as dominant negative regulator of GR activity, and it has b...
Autores principales: | Patel, Gaurang C., Liu, Yang, Millar, J. Cameron, Clark, Abbot F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770444/ https://www.ncbi.nlm.nih.gov/pubmed/29339763 http://dx.doi.org/10.1038/s41598-018-19262-9 |
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