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Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical inflammasome. Pathogens such as Francisella novicida express an under-acylated lipid A and escape caspase-11 recognition in mice. Here, we...

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Detalles Bibliográficos
Autores principales:	Lagrange, Brice, Benaoudia, Sacha, Wallet, Pierre, Magnotti, Flora, Provost, Angelina, Michal, Fanny, Martin, Amandine, Di Lorenzo, Flaviana, Py, Bénédicte F., Molinaro, Antonio, Henry, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770465/ https://www.ncbi.nlm.nih.gov/pubmed/29339744 http://dx.doi.org/10.1038/s41467-017-02682-y

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