Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia

The genomes of myeloid malignancies are characterized by epigenomic abnormalities. Heterozygous, inactivating ten-eleven translocation 2 (TET2) mutations and neomorphic isocitrate dehydrogenase (IDH) mutations are recurrent and mutually exclusive in acute myeloid leukaemia genomes. Ascorbic acid (vi...

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Detalles Bibliográficos
Autores principales: Mingay, M, Chaturvedi, A, Bilenky, M, Cao, Q, Jackson, L, Hui, T, Moksa, M, Heravi-Moussavi, A, Humphries, R K, Heuser, M, Hirst, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770587/
https://www.ncbi.nlm.nih.gov/pubmed/28663574
http://dx.doi.org/10.1038/leu.2017.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770587/
https://www.ncbi.nlm.nih.gov/pubmed/28663574
http://dx.doi.org/10.1038/leu.2017.171

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