Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

Heterozygous GATA2 mutations underlie an array of complex hematopoietic and lymphatic diseases. Analysis of the literature reporting three recurrent GATA2 germline (g) mutations (gT354M, gR396Q and gR398W) revealed different phenotype tendencies. Although all three mutants differentially predispose...

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Detalles Bibliográficos
Autores principales: Chong, C-E, Venugopal, P, Stokes, P H, Lee, Y K, Brautigan, P J, Yeung, D T O, Babic, M, Engler, G A, Lane, S W, Klingler-Hoffmann, M, Matthews, J M, D'Andrea, R J, Brown, A L, Hahn, C N, Scott, H S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770593/
https://www.ncbi.nlm.nih.gov/pubmed/28642594
http://dx.doi.org/10.1038/leu.2017.196

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