Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)

Alum, the well‐known vaccine adjuvant with a long history of clinical use, is changed from a “gel” to nanoparticles. This changes its mechanism of action from a “depot” that resides at the injection site, to nanoparticles that transport antigen and adjuvant into the lymph node. As reported by Xun Su...

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Autores principales: Jiang, Hao, Wang, Qin, Li, Lin, Zeng, Qin, Li, Hanmei, Gong, Tao, Zhang, Zhirong, Sun, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770673/
http://dx.doi.org/10.1002/advs.201870001
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author Jiang, Hao
Wang, Qin
Li, Lin
Zeng, Qin
Li, Hanmei
Gong, Tao
Zhang, Zhirong
Sun, Xun
author_facet Jiang, Hao
Wang, Qin
Li, Lin
Zeng, Qin
Li, Hanmei
Gong, Tao
Zhang, Zhirong
Sun, Xun
author_sort Jiang, Hao
collection PubMed
description Alum, the well‐known vaccine adjuvant with a long history of clinical use, is changed from a “gel” to nanoparticles. This changes its mechanism of action from a “depot” that resides at the injection site, to nanoparticles that transport antigen and adjuvant into the lymph node. As reported by Xun Sun and co‐workers in article number 1700426, this lymph node targeting strategy significantly improves the efficacy of vaccinations and offers a potential nanovaccine platform for treating cancer and other diseases. [Image: see text]
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spelling pubmed-57706732018-01-26 Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018) Jiang, Hao Wang, Qin Li, Lin Zeng, Qin Li, Hanmei Gong, Tao Zhang, Zhirong Sun, Xun Adv Sci (Weinh) Cover Picture Alum, the well‐known vaccine adjuvant with a long history of clinical use, is changed from a “gel” to nanoparticles. This changes its mechanism of action from a “depot” that resides at the injection site, to nanoparticles that transport antigen and adjuvant into the lymph node. As reported by Xun Sun and co‐workers in article number 1700426, this lymph node targeting strategy significantly improves the efficacy of vaccinations and offers a potential nanovaccine platform for treating cancer and other diseases. [Image: see text] John Wiley and Sons Inc. 2018-01-17 /pmc/articles/PMC5770673/ http://dx.doi.org/10.1002/advs.201870001 Text en © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Jiang, Hao
Wang, Qin
Li, Lin
Zeng, Qin
Li, Hanmei
Gong, Tao
Zhang, Zhirong
Sun, Xun
Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title_full Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title_fullStr Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title_full_unstemmed Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title_short Vaccine Delivery: Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses (Adv. Sci. 1/2018)
title_sort vaccine delivery: turning the old adjuvant from gel to nanoparticles to amplify cd8(+) t cell responses (adv. sci. 1/2018)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770673/
http://dx.doi.org/10.1002/advs.201870001
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