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The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer worldwide, ranking as high as the second leading cause of cancer-related deaths in industrialized countries. Consistent with immunosurveillance theory, the immune system is crucial to protect the host from developing tumors, and the major playe...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770731/ https://www.ncbi.nlm.nih.gov/pubmed/29375559 http://dx.doi.org/10.3389/fimmu.2017.01900 |
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author | Niccolai, Elena Ricci, Federica Russo, Edda Nannini, Giulia Emmi, Giacomo Taddei, Antonio Ringressi, Maria Novella Melli, Filippo Miloeva, Manouela Cianchi, Fabio Bechi, Paolo Prisco, Domenico Amedei, Amedeo |
author_facet | Niccolai, Elena Ricci, Federica Russo, Edda Nannini, Giulia Emmi, Giacomo Taddei, Antonio Ringressi, Maria Novella Melli, Filippo Miloeva, Manouela Cianchi, Fabio Bechi, Paolo Prisco, Domenico Amedei, Amedeo |
author_sort | Niccolai, Elena |
collection | PubMed |
description | Colorectal cancer (CRC) is the third most common cancer worldwide, ranking as high as the second leading cause of cancer-related deaths in industrialized countries. Consistent with immunosurveillance theory, the immune system is crucial to protect the host from developing tumors, and the major players in tumoral immunity are effector T cells. Anyway, cancer cells develop strategies of immunoevasion influencing the cancer-specific lymphocyte priming, activation, and effector function. Therefore, the T cell subsets that mature during the stages of tumor growth, differently contribute to disease progression and/or regression. In our study, we analyzed the intra-tumoral and peripheral T cell subsets’ distribution in 30 patients with CRC, in order to clarify their functional role toward cancer. We found that percentage of infiltrating effector T cells decreased in cancer tissue than in healthy mucosa and that the tumor microenvironment negatively influences the cytolytic activity of T lymphocytes reactive to cancer cells. Moreover, we found that the tumor tissue was infiltrated by a large amount of “not effector” T (neT) cells with a regulatory or an anergic profile, which are unable to kill cancer cells, may be contributing to the CRC promotion. The presence of neT cells was investigated also in the peripheral blood of CRC patients, demonstrating that the peripheral T regulatory cells can inhibit the proliferation of effector T cells, confirming their immunosuppressive properties. Finally, monitoring the changes in circulating neT cells’ frequencies after the tumor removal, we confirmed the role of cancer in the modulation of immune system, in particular, in supporting a Tregs-mediated immunosuppression. |
format | Online Article Text |
id | pubmed-5770731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57707312018-01-26 The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer Niccolai, Elena Ricci, Federica Russo, Edda Nannini, Giulia Emmi, Giacomo Taddei, Antonio Ringressi, Maria Novella Melli, Filippo Miloeva, Manouela Cianchi, Fabio Bechi, Paolo Prisco, Domenico Amedei, Amedeo Front Immunol Immunology Colorectal cancer (CRC) is the third most common cancer worldwide, ranking as high as the second leading cause of cancer-related deaths in industrialized countries. Consistent with immunosurveillance theory, the immune system is crucial to protect the host from developing tumors, and the major players in tumoral immunity are effector T cells. Anyway, cancer cells develop strategies of immunoevasion influencing the cancer-specific lymphocyte priming, activation, and effector function. Therefore, the T cell subsets that mature during the stages of tumor growth, differently contribute to disease progression and/or regression. In our study, we analyzed the intra-tumoral and peripheral T cell subsets’ distribution in 30 patients with CRC, in order to clarify their functional role toward cancer. We found that percentage of infiltrating effector T cells decreased in cancer tissue than in healthy mucosa and that the tumor microenvironment negatively influences the cytolytic activity of T lymphocytes reactive to cancer cells. Moreover, we found that the tumor tissue was infiltrated by a large amount of “not effector” T (neT) cells with a regulatory or an anergic profile, which are unable to kill cancer cells, may be contributing to the CRC promotion. The presence of neT cells was investigated also in the peripheral blood of CRC patients, demonstrating that the peripheral T regulatory cells can inhibit the proliferation of effector T cells, confirming their immunosuppressive properties. Finally, monitoring the changes in circulating neT cells’ frequencies after the tumor removal, we confirmed the role of cancer in the modulation of immune system, in particular, in supporting a Tregs-mediated immunosuppression. Frontiers Media S.A. 2017-12-22 /pmc/articles/PMC5770731/ /pubmed/29375559 http://dx.doi.org/10.3389/fimmu.2017.01900 Text en Copyright © 2017 Niccolai, Ricci, Russo, Nannini, Emmi, Taddei, Ringressi, Melli, Miloeva, Cianchi, Bechi, Prisco and Amedei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Niccolai, Elena Ricci, Federica Russo, Edda Nannini, Giulia Emmi, Giacomo Taddei, Antonio Ringressi, Maria Novella Melli, Filippo Miloeva, Manouela Cianchi, Fabio Bechi, Paolo Prisco, Domenico Amedei, Amedeo The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title | The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title_full | The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title_fullStr | The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title_full_unstemmed | The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title_short | The Different Functional Distribution of “Not Effector” T Cells (Treg/Tnull) in Colorectal Cancer |
title_sort | different functional distribution of “not effector” t cells (treg/tnull) in colorectal cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770731/ https://www.ncbi.nlm.nih.gov/pubmed/29375559 http://dx.doi.org/10.3389/fimmu.2017.01900 |
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