Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation

X-linked juvenile retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding retinoschisin (RS1), which leads to a significant proportion of visual impairment and blindness. To develop personalized genome editing based gene therapy, knock-in animal disease models that have th...

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Detalles Bibliográficos
Autores principales: Chen, Ding, Xu, Tao, Tu, Mengjun, Xu, Jinlin, Zhou, Chenchen, Cheng, Lulu, Yang, Ruqing, Yang, Tanchu, Zheng, Weiwei, He, Xiubin, Deng, Ruzhi, Ge, Xianglian, Li, Jin, Song, Zongming, Zhao, Junzhao, Gu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770790/
https://www.ncbi.nlm.nih.gov/pubmed/29379415
http://dx.doi.org/10.3389/fnmol.2017.00453

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