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Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

[Image: see text] The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models and is considered a causative factor for lung cancer in tobacco users. NNK is stereoselectively and reversibly metabolized to 4-(methylnitrosamino)-1...

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Detalles Bibliográficos
Autores principales:	Ma, Bin, Zarth, Adam T., Carlson, Erik S., Villalta, Peter W., Upadhyaya, Pramod, Stepanov, Irina, Hecht, Stephen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770887/ https://www.ncbi.nlm.nih.gov/pubmed/29131934 http://dx.doi.org/10.1021/acs.chemrestox.7b00281

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