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Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China

OBJECTIVES: To investigate the effects of gender on the association of serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. SETTING: Data were obtained from annual Jidong Oilfield employee and family member health checkups. The Jidong communit...

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Autores principales: Chen, Yue, Xia, Yunlong, Han, Xu, Yang, Yiheng, Yin, Xiaomeng, Qiu, Jing, Liu, Henghui, Zhou, Yong, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770963/
https://www.ncbi.nlm.nih.gov/pubmed/29275349
http://dx.doi.org/10.1136/bmjopen-2017-019037
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author Chen, Yue
Xia, Yunlong
Han, Xu
Yang, Yiheng
Yin, Xiaomeng
Qiu, Jing
Liu, Henghui
Zhou, Yong
Liu, Ying
author_facet Chen, Yue
Xia, Yunlong
Han, Xu
Yang, Yiheng
Yin, Xiaomeng
Qiu, Jing
Liu, Henghui
Zhou, Yong
Liu, Ying
author_sort Chen, Yue
collection PubMed
description OBJECTIVES: To investigate the effects of gender on the association of serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. SETTING: Data were obtained from annual Jidong Oilfield employee and family member health checkups. The Jidong community is geographically located in Tangshan City in northern China. PARTICIPANTS: A total of 9078 residents were invited to take part in the survey and provided informed consents. Individuals without data of ECG or SUA were excluded, leaving 8937 residents in our study. PRIMARY AND SECONDARY OUTCOME MEASURES: SUA was measured at baseline using the uricase-peroxidase method. Hyperuricaemia was defined as a SUA level >7.0 mg/dL in men and >5.7 mg/dL in women. AF was diagnosed based on ECG findings and/or any medical history of AF from referring physicians. The crude and independent association between SUA levels and AF prevalence was evaluated with logistic regression analysis. RESULTS: AF prevalence was 0.6% (53/8937). Participants with hyperuricaemia had a higher AF prevalence compared with those with normal SUA levels (1.1% vs 0.5%; P=0.02). Hyperuricaemia was correlated with AF after adjustment for various cardiovascular risk factors in all participants (P=0.03, OR 2.051, 95% CI 1.063 to 3.856). This correlation was particularly stronger in women compared with men (P<0.001, OR 6.366, 95% CI 2.553 to 15.871 in women and P=0.96, OR 1.025, 95% CI 0.400 to 2.626 in men). CONCLUSIONS: We demonstrated a significant association between increased SUA levels and AF prevalence in a Chinese population. Our data indicate that there is a gender-specific mechanism underlying the relationship between SUA and AF.
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spelling pubmed-57709632018-01-19 Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China Chen, Yue Xia, Yunlong Han, Xu Yang, Yiheng Yin, Xiaomeng Qiu, Jing Liu, Henghui Zhou, Yong Liu, Ying BMJ Open Cardiovascular Medicine OBJECTIVES: To investigate the effects of gender on the association of serum uric acid (SUA) levels and atrial fibrillation (AF) prevalence in a community-based Chinese population. SETTING: Data were obtained from annual Jidong Oilfield employee and family member health checkups. The Jidong community is geographically located in Tangshan City in northern China. PARTICIPANTS: A total of 9078 residents were invited to take part in the survey and provided informed consents. Individuals without data of ECG or SUA were excluded, leaving 8937 residents in our study. PRIMARY AND SECONDARY OUTCOME MEASURES: SUA was measured at baseline using the uricase-peroxidase method. Hyperuricaemia was defined as a SUA level >7.0 mg/dL in men and >5.7 mg/dL in women. AF was diagnosed based on ECG findings and/or any medical history of AF from referring physicians. The crude and independent association between SUA levels and AF prevalence was evaluated with logistic regression analysis. RESULTS: AF prevalence was 0.6% (53/8937). Participants with hyperuricaemia had a higher AF prevalence compared with those with normal SUA levels (1.1% vs 0.5%; P=0.02). Hyperuricaemia was correlated with AF after adjustment for various cardiovascular risk factors in all participants (P=0.03, OR 2.051, 95% CI 1.063 to 3.856). This correlation was particularly stronger in women compared with men (P<0.001, OR 6.366, 95% CI 2.553 to 15.871 in women and P=0.96, OR 1.025, 95% CI 0.400 to 2.626 in men). CONCLUSIONS: We demonstrated a significant association between increased SUA levels and AF prevalence in a Chinese population. Our data indicate that there is a gender-specific mechanism underlying the relationship between SUA and AF. BMJ Publishing Group 2017-12-22 /pmc/articles/PMC5770963/ /pubmed/29275349 http://dx.doi.org/10.1136/bmjopen-2017-019037 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiovascular Medicine
Chen, Yue
Xia, Yunlong
Han, Xu
Yang, Yiheng
Yin, Xiaomeng
Qiu, Jing
Liu, Henghui
Zhou, Yong
Liu, Ying
Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title_full Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title_fullStr Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title_full_unstemmed Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title_short Association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in China
title_sort association between serum uric acid and atrial fibrillation: a cross-sectional community-based study in china
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770963/
https://www.ncbi.nlm.nih.gov/pubmed/29275349
http://dx.doi.org/10.1136/bmjopen-2017-019037
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