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(131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization

Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glyco...

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Autores principales: Liu, Qiufang, Qian, Yuyi, Li, Panli, Zhang, Sihang, Liu, Jianjun, Sun, Xiaoguang, Fulham, Michael, Feng, Dagan, Huang, Gang, Lu, Wei, Song, Shaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771093/
https://www.ncbi.nlm.nih.gov/pubmed/29344306
http://dx.doi.org/10.7150/thno.21491
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author Liu, Qiufang
Qian, Yuyi
Li, Panli
Zhang, Sihang
Liu, Jianjun
Sun, Xiaoguang
Fulham, Michael
Feng, Dagan
Huang, Gang
Lu, Wei
Song, Shaoli
author_facet Liu, Qiufang
Qian, Yuyi
Li, Panli
Zhang, Sihang
Liu, Jianjun
Sun, Xiaoguang
Fulham, Michael
Feng, Dagan
Huang, Gang
Lu, Wei
Song, Shaoli
author_sort Liu, Qiufang
collection PubMed
description Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 ((131)I) to produce (131)I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy. In addition, it can also be imaged with single photon emission computed tomography (SPECT) imaging and photoacoustic imaging. Methods: We investigated the value of therapeutic and imaging of (131)I-HCuSNPs-MS-PTX in rats bearing Walker-256 tumor transplanted in the liver. After the intra-arterial (IA) injection of (131)I-HCuSNPs-MS-PTX, (18)F-Fluorodeoxyglucose ((18)F-FDG) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging was used to monitor the therapeutic effect. PET/CT findings were verified by immunohistochemical analysis. SPECT/CT and photoacoustic imaging were performed to demonstrate the distribution of (131)I-HCuSNPs-MS-PTX in vivo. Results: We found that embolization therapy in combination with chemotherapy, radiotherapy and photothermal therapy offered by (131)I-HCuSNPs-MS-PTX completely ablated the transplanted hepatic tumors at a relatively low dose. In comparison, embolization monotherapy or combination with one or two other therapies had less effective anti-tumor efficacy. The combination of SPECT/CT and photoacoustic imaging effectively confirmed microsphere delivery to the targeted tumors in vivo and guided the near-infrared laser irradiation. Conclusion: Our study suggests that there is a clinical theranostic potential for imaging-guided arterial embolization with (131)I-HCuSNPs-MS-PTX for the treatment of liver tumors.
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spelling pubmed-57710932018-01-17 (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization Liu, Qiufang Qian, Yuyi Li, Panli Zhang, Sihang Liu, Jianjun Sun, Xiaoguang Fulham, Michael Feng, Dagan Huang, Gang Lu, Wei Song, Shaoli Theranostics Research Paper Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 ((131)I) to produce (131)I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy. In addition, it can also be imaged with single photon emission computed tomography (SPECT) imaging and photoacoustic imaging. Methods: We investigated the value of therapeutic and imaging of (131)I-HCuSNPs-MS-PTX in rats bearing Walker-256 tumor transplanted in the liver. After the intra-arterial (IA) injection of (131)I-HCuSNPs-MS-PTX, (18)F-Fluorodeoxyglucose ((18)F-FDG) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging was used to monitor the therapeutic effect. PET/CT findings were verified by immunohistochemical analysis. SPECT/CT and photoacoustic imaging were performed to demonstrate the distribution of (131)I-HCuSNPs-MS-PTX in vivo. Results: We found that embolization therapy in combination with chemotherapy, radiotherapy and photothermal therapy offered by (131)I-HCuSNPs-MS-PTX completely ablated the transplanted hepatic tumors at a relatively low dose. In comparison, embolization monotherapy or combination with one or two other therapies had less effective anti-tumor efficacy. The combination of SPECT/CT and photoacoustic imaging effectively confirmed microsphere delivery to the targeted tumors in vivo and guided the near-infrared laser irradiation. Conclusion: Our study suggests that there is a clinical theranostic potential for imaging-guided arterial embolization with (131)I-HCuSNPs-MS-PTX for the treatment of liver tumors. Ivyspring International Publisher 2018-01-01 /pmc/articles/PMC5771093/ /pubmed/29344306 http://dx.doi.org/10.7150/thno.21491 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liu, Qiufang
Qian, Yuyi
Li, Panli
Zhang, Sihang
Liu, Jianjun
Sun, Xiaoguang
Fulham, Michael
Feng, Dagan
Huang, Gang
Lu, Wei
Song, Shaoli
(131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title_full (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title_fullStr (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title_full_unstemmed (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title_short (131)I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization
title_sort (131)i-labeled copper sulfide-loaded microspheres to treat hepatic tumors via hepatic artery embolization
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771093/
https://www.ncbi.nlm.nih.gov/pubmed/29344306
http://dx.doi.org/10.7150/thno.21491
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