A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

BACKGROUND: Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential applications in both biomedical research and therapy. Selecting the opsin with...

Descripción completa

Detalles Bibliográficos
Autores principales: Ballister, Edward R., Rodgers, Jessica, Martial, Franck, Lucas, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771134/
https://www.ncbi.nlm.nih.gov/pubmed/29338718
http://dx.doi.org/10.1186/s12915-017-0475-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771134/
https://www.ncbi.nlm.nih.gov/pubmed/29338718
http://dx.doi.org/10.1186/s12915-017-0475-2

Ejemplares similares