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A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling
BACKGROUND: Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential applications in both biomedical research and therapy. Selecting the opsin with...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771134/ https://www.ncbi.nlm.nih.gov/pubmed/29338718 http://dx.doi.org/10.1186/s12915-017-0475-2 |