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Reperfusion therapy in acute ischemic stroke: dawn of a new era?
Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, we present an extensive overview of intravenous and endovascular reperfusion strategies, re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771207/ https://www.ncbi.nlm.nih.gov/pubmed/29338750 http://dx.doi.org/10.1186/s12883-017-1007-y |
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author | Bhaskar, Sonu Stanwell, Peter Cordato, Dennis Attia, John Levi, Christopher |
author_facet | Bhaskar, Sonu Stanwell, Peter Cordato, Dennis Attia, John Levi, Christopher |
author_sort | Bhaskar, Sonu |
collection | PubMed |
description | Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, we present an extensive overview of intravenous and endovascular reperfusion strategies, recent advances in AIS neurointervention, limitations of various treatment paradigms, and provide insights on imaging-guided reperfusion therapies. A roadmap for imaging guided reperfusion treatment workflow in AIS is also proposed. Both systemic thrombolysis and endovascular treatment have been incorporated into the standard of care in stroke therapy. Further research on advanced imaging-based approaches to select appropriate patients, may widen the time-window for patient selection and would contribute immensely to early thrombolytic strategies, better recanalization rates, and improved clinical outcomes. |
format | Online Article Text |
id | pubmed-5771207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57712072018-01-26 Reperfusion therapy in acute ischemic stroke: dawn of a new era? Bhaskar, Sonu Stanwell, Peter Cordato, Dennis Attia, John Levi, Christopher BMC Neurol Review Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, we present an extensive overview of intravenous and endovascular reperfusion strategies, recent advances in AIS neurointervention, limitations of various treatment paradigms, and provide insights on imaging-guided reperfusion therapies. A roadmap for imaging guided reperfusion treatment workflow in AIS is also proposed. Both systemic thrombolysis and endovascular treatment have been incorporated into the standard of care in stroke therapy. Further research on advanced imaging-based approaches to select appropriate patients, may widen the time-window for patient selection and would contribute immensely to early thrombolytic strategies, better recanalization rates, and improved clinical outcomes. BioMed Central 2018-01-16 /pmc/articles/PMC5771207/ /pubmed/29338750 http://dx.doi.org/10.1186/s12883-017-1007-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Bhaskar, Sonu Stanwell, Peter Cordato, Dennis Attia, John Levi, Christopher Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title | Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title_full | Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title_fullStr | Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title_full_unstemmed | Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title_short | Reperfusion therapy in acute ischemic stroke: dawn of a new era? |
title_sort | reperfusion therapy in acute ischemic stroke: dawn of a new era? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771207/ https://www.ncbi.nlm.nih.gov/pubmed/29338750 http://dx.doi.org/10.1186/s12883-017-1007-y |
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