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Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed
AIM: The paper presents research on the most common causes of exposure that leads to disorders of cholinesterase activity, as well as an overview of the results of cholinesterase activity with the poisoned people. MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate comp...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771273/ https://www.ncbi.nlm.nih.gov/pubmed/29362639 http://dx.doi.org/10.3889/oamjms.2017.200 |
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author | Lutovac, Mitar Popova, Olga V. Jovanovic, Zoran Berisa, Hatidza Kristina, Radoman Ketin, Sonja Bojic, Marko |
author_facet | Lutovac, Mitar Popova, Olga V. Jovanovic, Zoran Berisa, Hatidza Kristina, Radoman Ketin, Sonja Bojic, Marko |
author_sort | Lutovac, Mitar |
collection | PubMed |
description | AIM: The paper presents research on the most common causes of exposure that leads to disorders of cholinesterase activity, as well as an overview of the results of cholinesterase activity with the poisoned people. MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate compounds has led to inhibition of AchE. A total number of examined workers are 175 in the chemical industry and agricultural production in the area of Rasina District-Serbia. RESULTS: The results showed that among workers who are constantly exposed to pesticides, acetylcholinesterase is within the reference value. Having examined the medical records of these workers, it is noted that, at 72%, there is a slight fall of AchE activity, each year. The workers who had been exposed to pesticides at the time of testing had acetylcholinesterase regarding reference value, but 52% of them had a few years ago significantly reduced the value of the activity of acetylcholinesterase, which was treated and then transferred to other jobs. The 48% of these workers had acetylcholinesterase regarding benchmarks or were transferred to other jobs, for a variety of other health problems. CONCLUSION: Using each pesticide should only deal with people who are well versed in the way of its use, as well as the way of protecting them from poisoning. |
format | Online Article Text |
id | pubmed-5771273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-57712732018-01-23 Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed Lutovac, Mitar Popova, Olga V. Jovanovic, Zoran Berisa, Hatidza Kristina, Radoman Ketin, Sonja Bojic, Marko Open Access Maced J Med Sci Public Health AIM: The paper presents research on the most common causes of exposure that leads to disorders of cholinesterase activity, as well as an overview of the results of cholinesterase activity with the poisoned people. MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate compounds has led to inhibition of AchE. A total number of examined workers are 175 in the chemical industry and agricultural production in the area of Rasina District-Serbia. RESULTS: The results showed that among workers who are constantly exposed to pesticides, acetylcholinesterase is within the reference value. Having examined the medical records of these workers, it is noted that, at 72%, there is a slight fall of AchE activity, each year. The workers who had been exposed to pesticides at the time of testing had acetylcholinesterase regarding reference value, but 52% of them had a few years ago significantly reduced the value of the activity of acetylcholinesterase, which was treated and then transferred to other jobs. The 48% of these workers had acetylcholinesterase regarding benchmarks or were transferred to other jobs, for a variety of other health problems. CONCLUSION: Using each pesticide should only deal with people who are well versed in the way of its use, as well as the way of protecting them from poisoning. Republic of Macedonia 2017-12-01 /pmc/articles/PMC5771273/ /pubmed/29362639 http://dx.doi.org/10.3889/oamjms.2017.200 Text en Copyright: © 2017 Mitar Lutovac, Olga V. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Public Health Lutovac, Mitar Popova, Olga V. Jovanovic, Zoran Berisa, Hatidza Kristina, Radoman Ketin, Sonja Bojic, Marko Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title | Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title_full | Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title_fullStr | Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title_full_unstemmed | Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title_short | Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed |
title_sort | management, diagnostic and prognostic significance of acetylcholinesterase as a biomarker of the toxic effects of pesticides in people occupationally exposed |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771273/ https://www.ncbi.nlm.nih.gov/pubmed/29362639 http://dx.doi.org/10.3889/oamjms.2017.200 |
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