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Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis

Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBAS...

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Autores principales: Yang, Yang, Zhang, Danhong, Zhou, Xia, Bao, Wuan, Ji, Yonglin, Sheng, Liming, Cheng, Lei, Chen, Ying, Du, Xianghui, Qiu, Guoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771351/
https://www.ncbi.nlm.nih.gov/pubmed/29344290
http://dx.doi.org/10.7150/jca.21465
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author Yang, Yang
Zhang, Danhong
Zhou, Xia
Bao, Wuan
Ji, Yonglin
Sheng, Liming
Cheng, Lei
Chen, Ying
Du, Xianghui
Qiu, Guoqin
author_facet Yang, Yang
Zhang, Danhong
Zhou, Xia
Bao, Wuan
Ji, Yonglin
Sheng, Liming
Cheng, Lei
Chen, Ying
Du, Xianghui
Qiu, Guoqin
author_sort Yang, Yang
collection PubMed
description Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the pooled hazard risks were obtained by the random-effects model. We also analyzed the brain metastasis (BM) risk in p-stage I patients without PCI. Results: Five retrospective studies were identified and a total of 1691 patients were included in our analysis, 315 of them received PCI. For all the resected patients, PCI was associated with improved overall survival (HR: 0.52, 95% CI: 0.33-0.82), and reduced brain metastasis risk (RR: 0.50, 95%CI: 0.32-0.78). However, with regard to p-stage I patients, no survival benefit was brought by PCI (HR: 0.87, 95% CI: 0.34-2.24). Moreover, the pooled analysis of 7 studies found that the 5-year brain metastasis risk was relatively low (12%, 95% CI: 8%-17%) for p-stage I patients without PCI. Conclusions: PCI might be associated with a favorable survival advantage and reduced BM risk in complete resected SCLC patients, except for p-stage I patients.
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spelling pubmed-57713512018-01-17 Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis Yang, Yang Zhang, Danhong Zhou, Xia Bao, Wuan Ji, Yonglin Sheng, Liming Cheng, Lei Chen, Ying Du, Xianghui Qiu, Guoqin J Cancer Research Paper Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the pooled hazard risks were obtained by the random-effects model. We also analyzed the brain metastasis (BM) risk in p-stage I patients without PCI. Results: Five retrospective studies were identified and a total of 1691 patients were included in our analysis, 315 of them received PCI. For all the resected patients, PCI was associated with improved overall survival (HR: 0.52, 95% CI: 0.33-0.82), and reduced brain metastasis risk (RR: 0.50, 95%CI: 0.32-0.78). However, with regard to p-stage I patients, no survival benefit was brought by PCI (HR: 0.87, 95% CI: 0.34-2.24). Moreover, the pooled analysis of 7 studies found that the 5-year brain metastasis risk was relatively low (12%, 95% CI: 8%-17%) for p-stage I patients without PCI. Conclusions: PCI might be associated with a favorable survival advantage and reduced BM risk in complete resected SCLC patients, except for p-stage I patients. Ivyspring International Publisher 2018-01-01 /pmc/articles/PMC5771351/ /pubmed/29344290 http://dx.doi.org/10.7150/jca.21465 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Yang, Yang
Zhang, Danhong
Zhou, Xia
Bao, Wuan
Ji, Yonglin
Sheng, Liming
Cheng, Lei
Chen, Ying
Du, Xianghui
Qiu, Guoqin
Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title_full Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title_fullStr Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title_full_unstemmed Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title_short Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
title_sort prophylactic cranial irradiation in resected small cell lung cancer: a systematic review with meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771351/
https://www.ncbi.nlm.nih.gov/pubmed/29344290
http://dx.doi.org/10.7150/jca.21465
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